Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1989 Apr;57(4):1339–1342. doi: 10.1128/iai.57.4.1339-1342.1989

Edema disease-like brain lesions in gnotobiotic piglets infected with Escherichia coli serotype O157:H7.

D H Francis 1, R A Moxley 1, C Y Andraos 1
PMCID: PMC313274  PMID: 2647636

Abstract

Gnotobiotic piglets inoculated with Escherichia coli serotype O157:H7 strains that produced Shiga-like toxin II developed brain lesions similar to those observed in edema disease of swine, including arteriolar necrosis and malacia. Loss of ability to produce Shiga-like toxin II resulted in loss of ability to cause brain lesions.

Full text

PDF
1339

Images in this article

1340Image
on p.1340
1341Image
on p.1341
1341Image
on p.1341

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Benfield D. A., Francis D. H., McAdaragh J. P., Johnson D. D., Bergeland M. E., Rossow K., Moore R. Combined rotavirus and K99 Escherichia coli infection in gnotobiotic pigs. Am J Vet Res. 1988 Mar;49(3):330–337. [PubMed] [Google Scholar]
  2. Clugston R. E., Nielsen N. O., Smith D. L. Experimental edema disease of swine (E. coli enterotoxemia). 3. Pathology and pathogenesis. Can J Comp Med. 1974 Jan;38(1):34–43. [PMC free article] [PubMed] [Google Scholar]
  3. Dobrescu L. New biological effect of edema disease principle (Escherichia coli-neurotoxin) and its use as an in vitro for this toxin. Am J Vet Res. 1983 Jan;44(1):31–34. [PubMed] [Google Scholar]
  4. Fong J. S., de Chadarevian J. P., Kaplan B. S. Hemolytic-uremic syndrome. Current concepts and management. Pediatr Clin North Am. 1982 Aug;29(4):835–856. doi: 10.1016/s0031-3955(16)34216-x. [DOI] [PubMed] [Google Scholar]
  5. Francis D. H., Collins J. E., Duimstra J. R. Infection of gnotobiotic pigs with an Escherichia coli O157:H7 strain associated with an outbreak of hemorrhagic colitis. Infect Immun. 1986 Mar;51(3):953–956. doi: 10.1128/iai.51.3.953-956.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gianantonio C. A., Vitacco M., Mendilaharzu F., Gallo G. E., Sojo E. T. The hemolytic-uremic syndrome. Nephron. 1973;11(2):174–192. doi: 10.1159/000180229. [DOI] [PubMed] [Google Scholar]
  7. Hall G. A., Chanter N., Bland A. P. Comparison in gnotobiotic pigs of lesions caused by verotoxigenic and non-verotoxigenic Escherichia coli. Vet Pathol. 1988 May;25(3):205–210. doi: 10.1177/030098588802500304. [DOI] [PubMed] [Google Scholar]
  8. Karmali M. A., Petric M., Lim C., Fleming P. C., Arbus G. S., Lior H. The association between idiopathic hemolytic uremic syndrome and infection by verotoxin-producing Escherichia coli. J Infect Dis. 1985 May;151(5):775–782. doi: 10.1093/infdis/151.5.775. [DOI] [PubMed] [Google Scholar]
  9. Keenan K. P., Sharpnack D. D., Collins H., Formal S. B., O'Brien A. D. Morphologic evaluation of the effects of Shiga toxin and E coli Shiga-like toxin on the rabbit intestine. Am J Pathol. 1986 Oct;125(1):69–80. [PMC free article] [PubMed] [Google Scholar]
  10. Kurtz H. J., Bergeland M. E., Barnes D. M. Pathologic changes in edema disease of swine. Am J Vet Res. 1969 May;30(5):791–806. [PubMed] [Google Scholar]
  11. Levine M. M. Escherichia coli that cause diarrhea: enterotoxigenic, enteropathogenic, enteroinvasive, enterohemorrhagic, and enteroadherent. J Infect Dis. 1987 Mar;155(3):377–389. doi: 10.1093/infdis/155.3.377. [DOI] [PubMed] [Google Scholar]
  12. Methiyapun S., Pohlenz J. F., Bertschinger H. U. Ultrastructure of the intestinal mucosa in pigs experimentally inoculated with an edema disease-producing strain of Escherichia coli (0139:K12:H1). Vet Pathol. 1984 Sep;21(5):516–520. doi: 10.1177/030098588402100511. [DOI] [PubMed] [Google Scholar]
  13. Morrison D. M., Tyrrell D. L., Jewell L. D. Colonic biopsy in verotoxin-induced hemorrhagic colitis and thrombotic thrombocytopenic purpura (TTP). Am J Clin Pathol. 1986 Jul;86(1):108–112. doi: 10.1093/ajcp/86.1.108. [DOI] [PubMed] [Google Scholar]
  14. O'Brien A. D., LaVeck G. D., Thompson M. R., Formal S. B. Production of Shigella dysenteriae type 1-like cytotoxin by Escherichia coli. J Infect Dis. 1982 Dec;146(6):763–769. doi: 10.1093/infdis/146.6.763. [DOI] [PubMed] [Google Scholar]
  15. Pai C. H., Kelly J. K., Meyers G. L. Experimental infection of infant rabbits with verotoxin-producing Escherichia coli. Infect Immun. 1986 Jan;51(1):16–23. doi: 10.1128/iai.51.1.16-23.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Riley L. W., Remis R. S., Helgerson S. D., McGee H. B., Wells J. G., Davis B. R., Hebert R. J., Olcott E. S., Johnson L. M., Hargrett N. T. Hemorrhagic colitis associated with a rare Escherichia coli serotype. N Engl J Med. 1983 Mar 24;308(12):681–685. doi: 10.1056/NEJM198303243081203. [DOI] [PubMed] [Google Scholar]
  17. Rose P. E., Armour J. A., Williams C. E., Hill F. G. Verotoxin and neuraminidase induced platelet aggregating activity in plasma: their possible role in the pathogenesis of the haemolytic uraemic syndrome. J Clin Pathol. 1985 Apr;38(4):438–441. doi: 10.1136/jcp.38.4.438. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Smith H. W., Green P., Parsell Z. Vero cell toxins in Escherichia coli and related bacteria: transfer by phage and conjugation and toxic action in laboratory animals, chickens and pigs. J Gen Microbiol. 1983 Oct;129(10):3121–3137. doi: 10.1099/00221287-129-10-3121. [DOI] [PubMed] [Google Scholar]
  19. Strockbine N. A., Marques L. R., Newland J. W., Smith H. W., Holmes R. K., O'Brien A. D. Two toxin-converting phages from Escherichia coli O157:H7 strain 933 encode antigenically distinct toxins with similar biologic activities. Infect Immun. 1986 Jul;53(1):135–140. doi: 10.1128/iai.53.1.135-140.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Tzipori S., Karch H., Wachsmuth K. I., Robins-Browne R. M., O'Brien A. D., Lior H., Cohen M. L., Smithers J., Levine M. M. Role of a 60-megadalton plasmid and Shiga-like toxins in the pathogenesis of infection caused by enterohemorrhagic Escherichia coli O157:H7 in gnotobiotic piglets. Infect Immun. 1987 Dec;55(12):3117–3125. doi: 10.1128/iai.55.12.3117-3125.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Tzipori S., Wachsmuth I. K., Chapman C., Birden R., Brittingham J., Jackson C., Hogg J. The pathogenesis of hemorrhagic colitis caused by Escherichia coli O157:H7 in gnotobiotic piglets. J Infect Dis. 1986 Oct;154(4):712–716. doi: 10.1093/infdis/154.4.712. [DOI] [PubMed] [Google Scholar]
  22. Weinstein D. L., Jackson M. P., Samuel J. E., Holmes R. K., O'Brien A. D. Cloning and sequencing of a Shiga-like toxin type II variant from Escherichia coli strain responsible for edema disease of swine. J Bacteriol. 1988 Sep;170(9):4223–4230. doi: 10.1128/jb.170.9.4223-4230.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES