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. 1989 Apr;57(4):1343–1346. doi: 10.1128/iai.57.4.1343-1346.1989

Effect of immunoglobulin M from normal human serum on Leishmania donovani promastigote agglutination, complement-mediated killing, and phagocytosis by human monocytes.

T R Navin 1, E C Krug 1, R D Pearson 1
PMCID: PMC313275  PMID: 2925255

Abstract

Serum from healthy, nonimmune humans contained immunoglobulin M (IgM) antibodies that agglutinated Leishmania donovani promastigotes, activated complement, and enhanced promastigote ingestion by human monocytes. The findings indicate that IgM antibodies have the capacity to affect the initial interaction of L. donovani promastigotes with human host defenses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berens R. L., Brun R., Krassner S. M. A simple monophasic medium for axenic culture of hemoflagellates. J Parasitol. 1976 Jun;62(3):360–365. [PubMed] [Google Scholar]
  2. Blackwell J. M., Ezekowitz R. A., Roberts M. B., Channon J. Y., Sim R. B., Gordon S. Macrophage complement and lectin-like receptors bind Leishmania in the absence of serum. J Exp Med. 1985 Jul 1;162(1):324–331. doi: 10.1084/jem.162.1.324. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Mosser D. M., Burke S. K., Coutavas E. E., Wedgwood J. F., Edelson P. J. Leishmania species: mechanisms of complement activation by five strains of promastigotes. Exp Parasitol. 1986 Dec;62(3):394–404. doi: 10.1016/0014-4894(86)90048-2. [DOI] [PubMed] [Google Scholar]
  4. Pearson R. D., Harcus J. L., Roberts D., Donowitz G. R. Differential survival of Leishmania donovani amastigotes in human monocytes. J Immunol. 1983 Oct;131(4):1994–1999. [PubMed] [Google Scholar]
  5. Pearson R. D., Manian A. A., Hall D., Harcus J. L., Hewlett E. L. Antileishmanial activity of chlorpromazine. Antimicrob Agents Chemother. 1984 May;25(5):571–574. doi: 10.1128/aac.25.5.571. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Pearson R. D., Steigbigel R. T. Mechanism of lethal effect of human serum upon Leishmania donovani. J Immunol. 1980 Nov;125(5):2195–2201. [PubMed] [Google Scholar]
  7. Wilson M. E., Pearson R. D. Evidence that Leishmania donovani utilizes a mannose receptor on human mononuclear phagocytes to establish intracellular parasitism. J Immunol. 1986 Jun 15;136(12):4681–4688. [PubMed] [Google Scholar]
  8. Wilson M. E., Pearson R. D. Roles of CR3 and mannose receptors in the attachment and ingestion of Leishmania donovani by human mononuclear phagocytes. Infect Immun. 1988 Feb;56(2):363–369. doi: 10.1128/iai.56.2.363-369.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]

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