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. 1989 Aug;57(8):2345–2349. doi: 10.1128/iai.57.8.2345-2349.1989

Recombinant murine gamma interferon induces enhanced resistance to Listeria monocytogenes infection in neonatal mice.

Y Chen 1, A Nakane 1, T Minagawa 1
PMCID: PMC313453  PMID: 2501217

Abstract

Neonatal mice within 24 h of birth were highly susceptible to intraperitoneal infection with Listeria monocytogenes. The 50% lethal dose of bacterial cells was 6.3 X 10(1) CFU for neonates and 3.2 X 10(6) CFU for adult mice. A single injection of recombinant murine gamma interferon (rMuIFN-gamma) protected neonatal mice from simultaneous challenge with a lethal dose of L. monocytogenes cells. The rMuIFN-gamma effect was dose dependent: protection was consistently observed in mice treated with rMuIFN-gamma at doses of more than 4 X 10(2) U (0.1 microgram of protein) per mouse. Bacterial growth in the spleens and livers of rMuIFN-gamma-treated neonates was significantly suppressed in comparison with that in the nontreated controls. The infected neonatal mice showed acquired antilisterial resistance against secondary intravenous infection after 4 weeks of age, and this resistance was significantly augmented in mice that had been treated with rMuIFN-gamma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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