Table.3.
Summary of the 4 patients with occult ACTH source.
| Patient number |
Age at diagnosis |
Sex | 24-UFC (microgram) |
8 am cortisol after HDSST (microgram/dl) |
MRI pituitary | Central to Peripheral ACTH ratio before CRH injection* |
Central to Peripheral ACTH ratio after CRH injection* |
Pituitary Surgery |
|---|---|---|---|---|---|---|---|---|
| 1 | 46 | M | 398 | N/A | No adenoma (questionable) |
1.1 | 1.2 | Yes, but no adenoma |
| 2† | 41 | F | 71.7 | 15.3 | Suspicious 0.6 cm adenoma |
1 1.1 |
1.5 1.1 |
Yes, but no ACTH staining |
| 3 | 27 | M | 1250 | 68 | No adenoma | 1.1 | 1.1 | Not done |
| 4 | 43 | F | 283 | 8.3 | Suspicious 0.5 cm adenoma |
1.2 | 1.6 | Not done |
*
CRH injection during IPSS study
†
IPSS done twice after initial pituitary surgery