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Infection and Immunity logoLink to Infection and Immunity
. 1989 Aug;57(8):2566–2568. doi: 10.1128/iai.57.8.2566-2568.1989

Evidence of coordinate regulation of virulence in Salmonella typhimurium involving the rsk element of the 95-kilobase plasmid.

J L Vandenbosch 1, D R Kurlandsky 1, R Urdangaray 1, G W Jones 1
PMCID: PMC313488  PMID: 2663728

Abstract

Integration of the Salmonella typhimurium virulence plasmid into the chromosome reduces mouse virulence, serum resistance, and HeLa cell adhesion-invasion while prolonging lag time in minimal medium. The proposed virulence plasmid regulatory element, rsk, partially restores virulence and fully restores the other three phenotypes to wild-type levels. Plasmid curing reduces virulence without affecting the other phenotypes. rsk has no apparent effect on the cured strain.

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Selected References

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