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. 1989 Aug;57(8):2586–2587. doi: 10.1128/iai.57.8.2586-2587.1989

Enhancement of growth of Mycobacterium lepraemurium in macrophages by gamma interferon.

N Mor 1, M B Goren 1, A J Crowle 1
PMCID: PMC313493  PMID: 2501220

Abstract

Gamma interferon, an immune lymphokine that protects mouse macrophages against infection by several parasites, was ineffective against Mycobacterium lepraemurium. On the contrary, it significantly stimulated multiplication of M. lepraemurium in the macrophages. Simultaneous treatment of macrophages with gamma interferon and interleukin-4 or interleukin-2 or a combination of all three did not enhance the macrophage resistance to infection with M. lepraemurium, but instead stimulated growth of M. lepraemurium.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alexander J., Smith C. C. Growth of Mycobacterium lepraemurium in nonstimulated and stimulated mouse peritoneal-derived and bone marrrow-derived macrophages in vitro. Infect Immun. 1978 Dec;22(3):631–636. doi: 10.1128/iai.22.3.631-636.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Belosevic M., Davis C. E., Meltzer M. S., Nacy C. A. Regulation of activated macrophage antimicrobial activities. Identification of lymphokines that cooperate with IFN-gamma for induction of resistance to infection. J Immunol. 1988 Aug 1;141(3):890–896. [PubMed] [Google Scholar]
  3. Douvas G. S., Looker D. L., Vatter A. E., Crowle A. J. Gamma interferon activates human macrophages to become tumoricidal and leishmanicidal but enhances replication of macrophage-associated mycobacteria. Infect Immun. 1985 Oct;50(1):1–8. doi: 10.1128/iai.50.1.1-8.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Flesch I. E., Kaufmann S. H. Attempts to characterize the mechanisms involved in mycobacterial growth inhibition by gamma-interferon-activated bone marrow macrophages. Infect Immun. 1988 Jun;56(6):1464–1469. doi: 10.1128/iai.56.6.1464-1469.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Mor N., Goren M. B. Discrepancy in assessment of phagosome-lysosome fusion with two lysosomal markers in murine macrophages infected with Candida albicans. Infect Immun. 1987 Jul;55(7):1663–1667. doi: 10.1128/iai.55.7.1663-1667.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Murray H. W. Interferon-gamma, the activated macrophage, and host defense against microbial challenge. Ann Intern Med. 1988 Apr;108(4):595–608. doi: 10.7326/0003-4819-108-4-595. [DOI] [PubMed] [Google Scholar]
  7. Ptak W., Gaugas J. M., Rees R. J., Allison A. C. Immune responses in mice with murine leprosy. Clin Exp Immunol. 1970 Jan;6(1):117–124. [PMC free article] [PubMed] [Google Scholar]
  8. Rook G. A., Steele J., Ainsworth M., Champion B. R. Activation of macrophages to inhibit proliferation of Mycobacterium tuberculosis: comparison of the effects of recombinant gamma-interferon on human monocytes and murine peritoneal macrophages. Immunology. 1986 Nov;59(3):333–338. [PMC free article] [PubMed] [Google Scholar]
  9. Walker L., Lowrie D. B. Killing of Mycobacterium microti by immunologically activated macrophages. Nature. 1981 Sep 3;293(5827):69–71. doi: 10.1038/293069a0. [DOI] [PubMed] [Google Scholar]
  10. Zurbrick B. G., Follett D. M., Czuprynski C. J. Cytokine regulation of the intracellular growth of Mycobacterium paratuberculosis in bovine monocytes. Infect Immun. 1988 Jul;56(7):1692–1697. doi: 10.1128/iai.56.7.1692-1697.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]

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