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. 1989 Sep;57(9):2906–2908. doi: 10.1128/iai.57.9.2906-2908.1989

Francisella tularensis-specific T-cell clones are human leukocyte antigen class II restricted, secrete interleukin-2 and gamma interferon, and induce immunoglobulin production.

H M Surcel 1, J Ilonen 1, K Poikonen 1, E Herva 1
PMCID: PMC313546  PMID: 2474506

Abstract

T-cell clones (TLC) were established from a Francisella tularensis-vaccinated subject in order to study the cells responsive for cell-mediated immunity against F. tularensis. All the clones were human leukocyte antigen (HLA) class II restricted to one of the HLA-DR specificities of the original donor. The TLC cells were CD4+ and produced interleukin-2 and gamma interferon after stimulation with specific antigen. Seven of the eight clones tested assisted in the production of immunoglobulin G (IgG), IgA, and IgM antibodies.

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Selected References

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