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. 1990 Sep;58(9):3158–3161. doi: 10.1128/iai.58.9.3158-3161.1990

Immunization with Treponema pallidum endoflagella alters the course of experimental rabbit syphilis.

C I Champion 1, J N Miller 1, L A Borenstein 1, M A Lovett 1, D R Blanco 1
PMCID: PMC313628  PMID: 2201648

Abstract

Rabbits were immunized over a 32-week period with a total of 450 micrograms of purified Treponema pallidum endoflagella. As measured by enzyme-linked immunosorbent assay, sera from immunized rabbits had antiendoflagellar antibody titers that were fivefold greater than titers of sera from infected immune rabbits and patients with secondary disease. Sera from all immunized animals possessed complement-dependent treponemicidal activity as measured by in vitro immobilization. Immunized animals challenged with virulent T. pallidum were not protected from symptomatic infection but showed an altered course of lesion development.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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