Figure 1.

Structure of VACV D13

(A) Stereo ribbon representation of a monomer of D13 colored from blue (N terminus) to red (C terminus). The turret is treated as a separate domain with α helices and β strands labeled with prefix “T” for clarity. The N-terminal helix present in D13^D513G is shown in magenta. The position of the D513G mutation is shown with a sphere, colored magenta, and labeled.

(B) Structure of the D13 trimer viewed from the side (left) and from below (right). Each subunit is colored separately, with N-terminal tails and turret domains being a darker shade compared to the jelly-rolls. Approximate molecular dimensions are shown, and the N-terminal helix present in D13^D513G is colored magenta. The black triangle denotes the molecular 3-fold symmetry axis.

See also Figure S1.