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. 1990 Oct;58(10):3455–3457. doi: 10.1128/iai.58.10.3455-3457.1990

Phase-variable lipopolysaccharide structures enhance the invasive capacity of Haemophilus influenzae.

J N Weiser 1, A Williams 1, E R Moxon 1
PMCID: PMC313677  PMID: 2401571

Abstract

Genes necessary for the expression and phase variation of lipopolysaccharide epitopes of a virulent Haemophilus influenzae type b isolate (RM.7004) are contained within two chromosomal loci designated lic-1 and lic-2. Mutations were introduced into both lic-1 and lic-2, and the virulence of the double mutant was compared with that of the wild type in infant rats. These mutations in RM.7004 resulted in a significantly reduced incidence of bacteremia following intranasal inoculation, although nasopharyngeal colonization was similar for the mutant and wild-type strains. In contrast, no differences in bacteremia were observed when the mutant and wild-type strains were inoculated intraperitoneally.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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