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. 1990 Nov;58(11):3810–3812. doi: 10.1128/iai.58.11.3810-3812.1990

Fab fragments from a monoclonal antibody against a germ tube mannoprotein block the yeast-to-mycelium transition in Candida albicans.

M Casanova 1, J P Martínez 1, W L Chaffin 1
PMCID: PMC313733  PMID: 2228250

Abstract

Fab fragments prepared from the immunoglobulin G monoclonal antibody (MAb) 4C12, which reacts with a determinant expressed on the hyphal extension of germ tubes of Candida albicans, inhibited germ tube formation, but intact MAb 4C12 did not. Indirect immunofluorescence showed a punctate binding pattern on cells incubated with Fab fragments but a confluent binding on cells incubated with intact MAb 4C12.

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Selected References

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