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. 1990 Dec;58(12):3954–3958. doi: 10.1128/iai.58.12.3954-3958.1990

Iron-regulated outer membrane protein of Bacteroides fragilis involved in heme uptake.

B R Otto 1, M Sparrius 1, A M Verweij-van Vught 1, D M MacLaren 1
PMCID: PMC313761  PMID: 2254022

Abstract

Under iron starvation, Bacteroides fragilis expresses various iron-regulated outer membrane proteins. In this study, a deferrated minimal medium was used in growth experiments, and the role of one of these iron-regulated outer membrane proteins (a 44-kDa protein) in an iron uptake mechanism which acquires iron from heme compounds was elucidated. When a specific 44-kDa protein antiserum was used in a medium with heme as the only iron source, growth inhibition was observed. These results demonstrate that the 44-kDa outer membrane protein plays an important role in the uptake of heme in B. fragilis.

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Selected References

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