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Plasma time-concentration profiles of MDMA (a) and MDA (b) and the corresponding pharmacokinetic parameters Cmax and AUC. All animals received an oral dose of 20 mg/kg MDMA. One group of rats received DXM (30 mg/kg i.p.) 1 and 0.25 hours before and 3 hours after MDMA was administered, while the second group of rats received saline as co-treatment. Values represent the mean ±SD (N=9–12 per group). Student’s t-test was performed and significance assumed when p<0.05.
