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. 1990 Dec;58(12):4045–4048. doi: 10.1128/iai.58.12.4045-4048.1990

Inhibition of heat-labile toxin from Bordetella parapertussis by fatty acids.

M Endoh 1, M Nagai 1, D L Burns 1, C R Manclark 1, Y Nakase 1
PMCID: PMC313774  PMID: 2254029

Abstract

The ability of heat-labile toxin (HLT) from Bordetella parapertussis to induce skin lesions in guinea pigs was found to be inhibited by lipids isolated from skin layers of adult mice, which are refractory to the lesion-inducing activity of HLT. These lipids were identified as linoleic and oleic acids. Other long-chain unsaturated fatty acids were also found to inhibit HLT; however, fatty alcohols, neutral lipids, phospholipids, cholesterol, prostaglandin, and leukotriene had no measurable effects on HLT action. The data presented in this report indicate that the ability of HLT to induce skin lesions in animals may depend, at least in part, on the free fatty acid content of the skin layer.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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