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Energy expenditure measured as VO2 in WT, Thra-0/0, and D2KO mice (Dio2−/−) with (A) and without (B) food. Water was provided ad libitum. Measurements were done for 24 h, at 22 C, with a total of 45–46 measurements per mouse with six mice per group. Note than in the presence of food Thra-0/0 mice have higher VO2 than the two other genotypes. In the absence of food, VO2 is expectedly lower and more so in Dio2−/−.
