Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1989 Jul;57(7):2246–2248. doi: 10.1128/iai.57.7.2246-2248.1989

Development of resistance to Trypanosoma cruzi in mice depends on a viable population of L3T4+ (CD4+) T lymphocytes.

F G Araujo 1
PMCID: PMC313867  PMID: 2499547

Abstract

Mice injected with monoclonal antibody to the L3T4+ (CD4+) cell membrane surface glycoprotein of T lymphocytes and immunized with antigens of Trypanosoma cruzi had reduced antibody and cell-mediated immune responses to the organism. Mortality in these mice was 100% following challenge with 1.5 x 10(5) trypanosomes, whereas controls had a 50% survival rate, indicating that T-cell activation and viable L3T4+ (CD4+) T lymphocytes are essential for the development of resistance.

Full text

PDF
2246

Images in this article

2247Image
on p.2247

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andrews N. W., Alves M. J., Schumacher R. I., Colli W. Trypanosoma cruzi: protection in mice immunized with 8-methoxypsoralen-inactivated trypomastigotes. Exp Parasitol. 1985 Dec;60(3):255–262. doi: 10.1016/0014-4894(85)90029-3. [DOI] [PubMed] [Google Scholar]
  2. Araujo F. G. Analysis of Trypanosoma cruzi antigens bound by specific antibodies and by antibodies to related trypanosomatids. Infect Immun. 1986 Jul;53(1):179–185. doi: 10.1128/iai.53.1.179-185.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Araujo F. G., Guptill D. Use of antigen preparations of the amastigote stage of Trypanosoma cruzi in the serology of Chagas' disease. Am J Trop Med Hyg. 1984 May;33(3):362–371. doi: 10.4269/ajtmh.1984.33.362. [DOI] [PubMed] [Google Scholar]
  4. Ben Younès-Chennoufi A., Said G., Eisen H., Durand A., Hontebeyrie-Joskowicz M. Cellular immunity to Trypanosoma cruzi is mediated by helper T cells (CD4+). Trans R Soc Trop Med Hyg. 1988;82(1):84–89. doi: 10.1016/0035-9203(88)90271-4. [DOI] [PubMed] [Google Scholar]
  5. Bottomly K. A functional dichotomy in CD4+ T lymphocytes. Immunol Today. 1988 Sep;9(9):268–274. doi: 10.1016/0167-5699(88)91308-4. [DOI] [PubMed] [Google Scholar]
  6. Cobbold S., Martin G., Waldmann H. Monoclonal antibodies for the prevention of graft-versus-host disease and marrow graft rejection. The depletion of T cell subsets in vitro and in vivo. Transplantation. 1986 Sep;42(3):239–247. doi: 10.1097/00007890-198609000-00003. [DOI] [PubMed] [Google Scholar]
  7. Dialynas D. P., Wilde D. B., Marrack P., Pierres A., Wall K. A., Havran W., Otten G., Loken M. R., Pierres M., Kappler J. Characterization of the murine antigenic determinant, designated L3T4a, recognized by monoclonal antibody GK1.5: expression of L3T4a by functional T cell clones appears to correlate primarily with class II MHC antigen-reactivity. Immunol Rev. 1983;74:29–56. doi: 10.1111/j.1600-065x.1983.tb01083.x. [DOI] [PubMed] [Google Scholar]
  8. Hontebeyrie-Joskowicz M., Said G., Milon G., Marchal G., Eisen H. L3T4+ T cells able to mediate parasite-specific delayed-type hypersensitivity play a role in the pathology of experimental Chagas' disease. Eur J Immunol. 1987 Jul;17(7):1027–1033. doi: 10.1002/eji.1830170720. [DOI] [PubMed] [Google Scholar]
  9. Hudson L. Autoimmune phenomena in chronic chagasic cardiopathy. Parasitol Today. 1985 Jul;1(1):6–9. doi: 10.1016/0169-4758(85)90099-7. [DOI] [PubMed] [Google Scholar]
  10. Israelski D. M., Araujo F. G., Conley F. K., Suzuki Y., Sharma S., Remington J. S. Treatment with anti-L3T4 (CD4) monoclonal antibody reduces the inflammatory response in toxoplasmic encephalitis. J Immunol. 1989 Feb 1;142(3):954–958. [PubMed] [Google Scholar]
  11. Kierszenbaum F., Howard J. G. Mechanisms of resistance against experimental Trypanosoma cruzi infection: the importance of antibodies and antibody-forming capacity in the Biozzi high and low responder mice. J Immunol. 1976 May;116(5):1208–1211. [PubMed] [Google Scholar]
  12. Kierszenbaum F. Is there autoimmunity in Chagas disease? Parasitol Today. 1985 Jul;1(1):4–6. doi: 10.1016/0169-4758(85)90098-5. [DOI] [PubMed] [Google Scholar]
  13. Minoprio P., Eisen H., Joskowicz M., Pereira P., Coutinho A. Suppression of polyclonal antibody production in Trypanosoma cruzi-infected mice by treatment with anti-L3T4 antibodies. J Immunol. 1987 Jul 15;139(2):545–550. [PubMed] [Google Scholar]
  14. Neal R. A., Johnson P. Immunization against Trypanosoma cruzi using killed antigens and with saponin as adjuvant. Acta Trop. 1977 Mar;34(1):87–96. [PubMed] [Google Scholar]
  15. Phillips S. M., Linette G. P., Doughty B. L., Byram J. E., Von Lichtenberg F. In vivo T cell depletion regulates resistance and morbidity in murine schistosomiasis. J Immunol. 1987 Aug 1;139(3):919–926. [PubMed] [Google Scholar]
  16. Roberson E. L., Hanson W. L. Trypanosoma cruzi: effects of anti-thymocyte serum in mice and neonatal thymectomy in rats. Exp Parasitol. 1973 Oct;34(2):168–180. doi: 10.1016/0014-4894(73)90076-3. [DOI] [PubMed] [Google Scholar]
  17. Schmunis G. A., Cappa S. M., Traversa O. C., Janovsky J. F. The effect of immuno-depression due to neonatal thymectomy on infections with Trypanosoma cruzi in mice. Trans R Soc Trop Med Hyg. 1971;65(1):89–94. doi: 10.1016/0035-9203(71)90190-8. [DOI] [PubMed] [Google Scholar]
  18. Scott M. T., Snary D. Protective immunisation of mice using cell surface glycoprotein from Trypanosoma cruzi. Nature. 1979 Nov 1;282(5734):73–74. doi: 10.1038/282073a0. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES