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. 1989 Jul;57(7):2249–2252. doi: 10.1128/iai.57.7.2249-2252.1989

Conservation of the biologically active portions of staphylococcal enterotoxins C1 and C2.

G A Bohach 1, P M Schlievert 1
PMCID: PMC313868  PMID: 2543637

Abstract

We determined the primary sequence of staphylococcal enterotoxin (SE) C2 by sequencing its cloned structural gene, entC2. The entC2 structural gene contains an 801-base-pair open reading frame which encodes a 266-amino-acid precursor with a molecular weight of 30,608. Mature SE C2, produced by removal of the signal peptide, contains 239 amino acids with a molecular weight of 27,531. A sequence comparison between SE C2 and SE C1 showed that the 167 carboxyl amino acids in both toxins were 100% conserved. In contrast, the 72 N-terminal residues were 10% divergent. This provides additional evidence that carboxyl regions of staphylococcal and streptococcal pyrogenic toxins determine shared biological activities and cross-reactive epitopes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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