Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1989 Jul;57(7):2253–2255. doi: 10.1128/iai.57.7.2253-2255.1989

Specific immunological unresponsiveness to bacterial lipopolysaccharides develops in a cyclic manner.

K L Elkins 1, P W Stashak 1, P J Baker 1
PMCID: PMC313869  PMID: 2471694

Abstract

Prior exposure (priming) of BALB/cByJ mice to a low dose of lipopolysaccharide derived from Escherichia coli 055 or Serratia marcescens, followed by immunization with an optimally immunogenic dose of the same lipopolysaccharide 2 to 30 days later, results in the expression of substantially reduced antibody responses. Such unresponsiveness, which is antigen specific, occurs in a cyclic manner with time after priming.

Full text

PDF
2253

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baker P. H., Stashak P. W. Quantitative and qualitative studies on the primary antibody response to pneumococcal polysaccharides at ehe cellular level. J Immunol. 1969 Dec;103(6):1342–1348. [PubMed] [Google Scholar]
  2. Baker P. J., Amsbaugh D. F., Stashak P. W., Caldes G., Prescott B. Regulation of the antibody response to pneumococcal polysaccharide by thymus-derived cells. Rev Infect Dis. 1981 Mar-Apr;3(2):332–341. doi: 10.1093/clinids/3.2.332. [DOI] [PubMed] [Google Scholar]
  3. Baker P. J., Hiernaux J. R., Stashak P. W., Rudbach J. A. Cyclic development of immunological memory to bacterial lipopolysaccharide. Infect Immun. 1985 Apr;48(1):1–6. doi: 10.1128/iai.48.1.1-6.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Baker P. J., Stashak P. W., Prescott B. Use of erythrocytes sensitized with purified pneumococcal polysaccharides for the assay of antibody and antibody-producing cells. Appl Microbiol. 1969 Mar;17(3):422–426. doi: 10.1128/am.17.3.422-426.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Britton S., Wepsic T., Möller G. Persistence of immunogenicity of two complex antigens retained in vivo. Immunology. 1968 Apr;14(4):491–501. [PMC free article] [PubMed] [Google Scholar]
  6. Elkins K. L., Stashak P. W., Baker P. J. Mechanisms of specific immunological unresponsiveness to bacterial lipopolysaccharides. Infect Immun. 1987 Dec;55(12):3093–3102. doi: 10.1128/iai.55.12.3093-3102.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Elkins K. L., Stashak P. W., Baker P. J. Prior exposure to subimmunogenic amounts of some bacterial lipopolysaccharides induces specific immunological unresponsiveness. Infect Immun. 1987 Dec;55(12):3085–3092. doi: 10.1128/iai.55.12.3085-3092.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gottlieb C. F. Application of transformations to normalize the distribution of plaque-forming cells. J Immunol. 1974 Jul;113(1):51–57. [PubMed] [Google Scholar]
  9. Hiernaux J. R., Jones J. M., Rudbach J. A., Rollwagen F., Baker P. J. Antibody response of immunodeficient (xid) CBA/N mice to Escherichia coli 0113 lipopolysaccharide, a thymus-independent antigen. J Exp Med. 1983 Apr 1;157(4):1197–1207. doi: 10.1084/jem.157.4.1197. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Rosenstreich D. L., Vogel S. N., Jacques A., Wahl L. M., Scher I., Mergenhagen S. E. Differential endotoxin sensitivity of lymphocytes and macrophages from mice with an X-linked defect in B cell maturation. J Immunol. 1978 Aug;121(2):685–690. [PubMed] [Google Scholar]
  11. Rudbach J. A., Reed N. D. Immunological responses of mice to lipopolysaccharide: lack of secondary responsiveness by C3H/HeJ mice. Infect Immun. 1977 May;16(2):513–517. doi: 10.1128/iai.16.2.513-517.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Stashak P. W., Taylor C. E., Caldes G., Prescott B., Baker P. J. Cyclic expression of low-dose paralysis. Cell Immunol. 1983 Apr 1;77(1):143–149. doi: 10.1016/0008-8749(83)90014-x. [DOI] [PubMed] [Google Scholar]
  13. Taylor C. E., Amsbaugh D. F., Stashak P. W., Caldes G., Prescott B., Baker P. J. Cell surface antigens and other characteristics of T cells regulating the antibody response to type III pneumococcal polysaccharide. J Immunol. 1983 Jan;130(1):19–23. [PubMed] [Google Scholar]
  14. Von Eschen K. B., Rudbach J. A. Dissociation of the anti-hapten and anti-carrier responses of mice injected with dinitrophenylated lipopolysaccharide. Infect Immun. 1981 Jan;31(1):327–333. doi: 10.1128/iai.31.1.327-333.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Von Eschen K. B., Rudbach J. A. Immunological responses of mice to native protoplasmic polysaccharide and lipopolysaccharide: functional separation of the two signals required to stimulate a secondary antibody response. J Exp Med. 1974 Dec 1;140(6):1604–1614. doi: 10.1084/jem.140.6.1604. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Weigle W. O. Cyclical production of antibody as a regulatory mechanism in the immune response. Adv Immunol. 1975;21:87–111. doi: 10.1016/s0065-2776(08)60219-9. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES