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. Author manuscript; available in PMC: 2012 Feb 11.
Published in final edited form as: Oncogene. 2011 Mar 21;30(32):3522–3536. doi: 10.1038/onc.2011.70

Figure 2.

Figure 2

Genes overlapping between the Pten;Kras;Amhr2-cre gene signature and relevant signatures from human cancers. (A) Overlaps between the set of human orthologs high (fold>2) in Pten;Kras;Amhr2-cre mice (compared to wild-type mice) and various sets of genes derived from human datasets: genes high/low (p<0.01, t-test) in k-ras mutant versus k-ras wild-type cell lines, and genes high/low (p<0.05) in serous, mucinous, or endometrioid ovarian cancers, as compared to normal ovary. Numbers of genes in each set indicated in parentheses. Numbers overlapping between sets were compared to chance expected. (B) Heat maps showing expression patterns for the Pten;Kras;Amhr2-cre gene signature, both in the Pten;Kras;Amhr2-cre mouse expression dataset and in an expression dataset of human cancer cell lines with or without mutations in kras (35). (C) Heat maps for the Pten;Kras;Amhr2-cre gene signature, both in the mouse dataset and in a dataset of human ovarian tumors (36). For parts B and C, genes represented in both heat maps are the same and have the same ordering, and genes not represented in the given human dataset are not shown.