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. 2010 Jul 13;133(8):2475–2488. doi: 10.1093/brain/awq159

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© The Author (2010). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

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Sumatriptan-induced latent sensitization. Rats were pre-exposed to sumatriptan infusion and co-infusion of vehicle or NXN-323 for 6 days. The rats were challenged with sodium nitroprusside, which produced significant (P < 0.05) reductions in paw withdrawal thresholds in both vehicle-exposed and NXN-323-treated rats that also received sumatriptan infusion. Two-factor ANOVA indicated no significant (P > 0.05) differences withdrawal thresholds between the sumatriptan-infused groups receiving vehicle and that receiving NXN-323.