Figure 4.

Changes in C-index for cardiovascular disease risk prediction from addition of adiposity measures or conventional risk factors to a model containing age and sex only

Analyses were based on 144 795 participants (8347 cardiovascular events) in 39 studies. Analyses were restricted to participants with BMI of 20 kg/m² or higher. BMI=body-mass index. *Reference C-index was 0·6741 (95% CI 0·6685 to 0·6798) for the model including age and stratified by sex. †p=0·0001 for change in C-index after addition of waist circumference into the model with age, sex, and BMI. ‡p<0·0001 for change in C-index after addition of waist-to-hip ratio into the model with age, sex, and BMI. §Smoking status, systolic blood pressure, and history of diabetes. ¶Smoking status, systolic blood pressure, history of diabetes, and total and HDL cholesterol.