Table 1.
Control subject N | Age/gender/race | PMI | Storage time (months)a | Cause of death | Psychotropic medicationb | Drugs/alcoholc | Toxicology |
---|---|---|---|---|---|---|---|
1c | 27/F/C | 15 | 73 | N | None | None | None detected |
2c | 30/M/AAm | 19 | 63 | N | None | None | None detected |
3c | 35/M/C | 25 | 66 | N | None | None | lidocaine |
4c | 37/F/C | 13 | 41 | N | None | None | prochlorperazine |
5c | 43/M/C | 23 | 57 | N | None | None | propoxyphene, |
norpropoxyphene, | |||||||
oxycodone | |||||||
6c | 46/F/C | 27 | 77 | H | None | None | None detected |
7c | 46/M/AAm | 11 | 58 | N | None | AA for 3 years. | None detected |
Not at the time of death | |||||||
8c | 50/F/C | 27 | 65 | N | None | None | None detected |
9c | 54/M/AAm | 17 | 66 | N | clonazepamd | None | brompheniramine |
10c | 60/F/AAm | 19 | 85 | N | None | None | None detected |
11c | 70/M/C | 29 | 72 | N | clonazepamb,e | AA 30 years ago | None detected |
12c | 71/M/C | 24 | 95 | N | None | AD for 20 years. | None detected |
Stopped 32 yearrs ago | |||||||
13c | 77/M/C | 24 | 87 | N | None | None | None detected |
14c | 80/F/C | 21 | 58 | N | None | None | None detected |
15c | 86/F/C | 18 | 45 | N | None | None | diltiazem, sodium 124, potassium 9.3 |
Average | 54.1 ± 18.3 | 20.80 ± 5.21 | 67.47 ± 14.98 |
Major depressive disorder subject N | Age/gender/race | PMI | Storage time (months)a | Cause of death | Psychotropic medicationb | Drugs/Alcoholc | Toxicology | Duration of depression (years)f | Age of onset |
---|---|---|---|---|---|---|---|---|---|
1 | 34/F/C | 27 | 67 | S | trazodone, | None | CO, alprazolam | 20 | 14 |
alprazolam,b | |||||||||
risperidone | |||||||||
2g | 30/M/AAm | 18 | 93 | S | None | AA for 4 years. | EtOH | 3 | 27 |
Not at the time of death | |||||||||
3 | 36/M/C | 11 | 46 | U | None | None | diphenhydramine, | 3 | 33 |
4h | 40/F/C | 25 | 66 | HEART, other acc.OD | temazepam,b | DA | mophine, codeine, | 3 | 35 |
fluoxetineb | hydrocodone, | ||||||||
diphenylhydramine | |||||||||
5 | 42/F/C | 24 | 89 | S | fluoxetine,b | DA | propoxyphene, | 26 | 15 |
amitriptyline,b | acetaminophen | ||||||||
paroxetine,b | |||||||||
diazepamb | |||||||||
6 | 42/M/C | 20 | 82 | S | sertralineb | None | sertraline, | 2 | 40 |
diphenylhydramine | |||||||||
7 | 46/M/AAm | 17 | 89 | H | None | None | None detected | 1 | 45 |
8 | 50/F/C | 23 | 82 | S | clomipramine, | None | None detected | 4 | 45 |
fluoxetine, | |||||||||
thiothixene | |||||||||
9 | 54/M/C | 23 | 89 | Ac | sertralineb | None | CO, phenobarbital, | 3 | 51 |
phenytoin | |||||||||
10 | 63/F/C | 24 | 88 | N | chlorpromazine,b | PS (20 years), | 30 | 33 | |
clonazepam,b | AD(25 years) | ||||||||
amitriptylineb | |||||||||
11g | 73/F/C | 17 | 81 | N | lithium,b | AD for 40 years. | None detected | 50 | 23 |
nortriptyline, | Stopped 8 years before death | ||||||||
restoril, | |||||||||
clonazepamb | |||||||||
12 | 73/M/C | 10 | 95 | S | nortriptylineb | None | nortriptyline, EtOH | 5 | 69 |
13 | 74/M/C | 25 | 81 | S | chlorpromazine, | PS | diazepam, | 24 | 50 |
trazodone, | acetaminophen | ||||||||
clorazepate, | |||||||||
methylphenidate | |||||||||
14 | 78/F/C | 25 | 83 | S | lorazepam | None | None detected | 5 | 73 |
15 | 86/M/C | 21 | 81 | S | fluoxetine,b | None | None detected | 30 | 55 |
atenolol | |||||||||
Average | 54.7717.6 | 20.6774.98 | 80.67712.27 |
AA, alcohol abuse; AAm, African American; Ac, accident; AD, alcohol dependence; C, caucasian; CO, carbon monoxide; D, drug abuse; DA, drug addiction; F, female; H, homicide; Hx, history; M, male; N, natural; PMI, post-mortem interval (hour; defined as the time between death and the beginning of freezing at −80°C); PS, polysubstance abuse; S, suicide; U, undetermined.
Storage time refers to the duration between date of the brain tissue being collected for homogenization and the date of death.
Drugs that were prescribed in the last month of life.
Defined as psychoactive substance use disorder.
Prescribed for bursitis, degenerative joint disease, and fibromyalgia.
Prescribed for restless leg syndrome.
The duration of illness covers the time between the first display (and not necessarily diagnosis) of symptoms of a depressive illness and the date of death.
This subjects previously met diagnostic criteria for alcohol abuse at 2 and 8 years prior to death.
Recurrent MD, in full remission.