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. 2011 Jul 13;8:56. doi: 10.1186/1742-4690-8-56

Table 1.

Genotypic prediction of HIV-1 subtype D tropism compared to the TTT phenotypic assay

TTT Concordance Genotypic Prediction
Genotypic tool R5 R5X4/X4 Sena Speb
Geno2pheno10 R5 12 1 58% 75% 54%
X4 10 3 κ = 0.15 (p = 0.14)
Combined 11/25 and net charge rules R5 15 0 73% 100% 68%
X4 7 4 κ = 0.40 (p < 0.01)

aSen: sensitivity is the capacity for detecting CXCR4-using viruses, calculated by the number of concordant X4/R5X4 results divided by the number of viruses phenotyped as R5X4/X4.

bSpe: specificity is the capacity for detecting exclusive CCR5-using viruses, calculated by the number of concordant R5 results divided by the number of viruses phenotyped as R5.

κ: kappa coefficient.