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. 1967 Jan;93(1):40–46. doi: 10.1128/jb.93.1.40-46.1967

Antibodies in Histoplasmosis

Harold Markowitz 1
PMCID: PMC314965  PMID: 6020413

Abstract

Production of precipitating and complement-fixing antibody in rabbits and other animals was induced by immunization with live yeast-phase cells of Histoplasma capsulatum. Results of studies of polysaccharide antigens from three strains of H. capsulatum, by quantitative complement-fixation with human and rabbit antisera, strongly suggest the presence of type specificity. The variations of titer during 11 weeks in one patient with histoplasmosis and the variations of titer among a group of patients with histoplasmosis were studied by use of quantitative complement-fixation tests.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANACKER R. L., MUNOZ J. Mouse antibody. I. Characterization and properties of antibody in mouse peritoneal fluid. J Immunol. 1961 Oct;87:426–432. [PubMed] [Google Scholar]
  2. CAMPBELL C. C. Antigenic fractions of Histoplasma capsulatum. Am J Public Health Nations Health. 1953 Jun;43(6 Pt 1):712–717. doi: 10.2105/ajph.43.6_pt_1.712. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. GREENE C. H., DELALLA L. S., TOMPKINS V. N. Separation of specific antigens of Histoplasma capsulatum by ion-exchange chromatography. Proc Soc Exp Biol Med. 1960 Oct;105:140–141. doi: 10.3181/00379727-105-26037. [DOI] [PubMed] [Google Scholar]
  4. HEINER D. C. Diagnosis of histoplasmosis using precipitin reactions in agargel. Pediatrics. 1958 Oct;22(4 Pt 1):616–627. [PubMed] [Google Scholar]
  5. KNIGHT R. A., MARCUS S. Polysaccharide skin test antigens derived from Histoplasma capsulatum and Blastomyces dermatitidis. Am Rev Tuberc. 1958 Jun;77(6):983–989. doi: 10.1164/artpd.1958.77.6.983. [DOI] [PubMed] [Google Scholar]
  6. Kaufman L., Blumer S. Occurrence of serotypes among Histoplasma capsulatum strains. J Bacteriol. 1966 Apr;91(4):1434–1439. doi: 10.1128/jb.91.4.1434-1439.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. LABZOFFSKY N. A., FISCHER J. B. A simple method of preparing an antigen from Histoplasma capsulatum for use in the complement fixation test. Can J Microbiol. 1955 Aug;1(7):520–524. doi: 10.1139/m55-065. [DOI] [PubMed] [Google Scholar]
  8. MARKOWITZ H. POLYSACCHARIDE ANTIGENS FROM HISTOPLASMA CAPSULATUM. Proc Soc Exp Biol Med. 1964 Mar;115:697–700. doi: 10.3181/00379727-115-29010. [DOI] [PubMed] [Google Scholar]
  9. Markham R. A steam distillation apparatus suitable for micro-Kjeldahl analysis. Biochem J. 1942 Dec;36(10-12):790–791. doi: 10.1042/bj0360790. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. OSLER A. G., STRAUSS J. H., MAYER M. M. Diagnostic complement fixation. I. A method. Am J Syph Gonorrhea Vener Dis. 1952 Mar;36(2):140–153. [PubMed] [Google Scholar]
  11. PINE L. Studies on the growth of Histoplasma capsulatum. I. Growth of the yeast phase in liquid media. J Bacteriol. 1954 Dec;68(6):671–679. doi: 10.1128/jb.68.6.671-679.1954. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. SALVIN S. B., FURCOLOW M. L. Precipitins in human histoplasmosis. J Lab Clin Med. 1954 Feb;43(2):259–274. [PubMed] [Google Scholar]
  13. SALVIN S. B., SMITH R. F. Antigens from the yeast phase of Histoplasma capsulatum. III. Isolation, properties, and activity of a protein-carbohydrate complex. J Infect Dis. 1959 Jul-Aug;105(1):45–53. doi: 10.1093/infdis/105.1.45. [DOI] [PubMed] [Google Scholar]
  14. SCHUBERT J. H., AJELLO L., COOPER J. S., RUNYON L. C. Evaluation of histoplasmin and yeast phase antigens derived from a single strain of Histoplasma capsulatum in the complement fixation test. J Bacteriol. 1955 May;69(5):558–562. doi: 10.1128/jb.69.5.558-562.1955. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. SCHUBERT J. H., AJELLO L. Variation in complement fixation antigenicity of different yeast phase strains of Histoplasma capsulatum. J Lab Clin Med. 1957 Aug;50(2):304–307. [PubMed] [Google Scholar]
  16. SORENSEN L. J., EVANS E. E. Antigenic fractions specific for Histoplasma capsulatum in the complement fixation reaction. Proc Soc Exp Biol Med. 1954 Nov;87(2):339–341. doi: 10.3181/00379727-87-21374. [DOI] [PubMed] [Google Scholar]
  17. WIGGINS G. L., SCHUBERT J. H. RELATIONSHIP OF HISTOPLASMIN AGAR-GEL BANDS AND COMPLEMENT-FIXATION TITERS IN HISTOPLASMOSIS. J Bacteriol. 1965 Mar;89:589–596. doi: 10.1128/jb.89.3.589-596.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. WILSON J. W. Therapy of systemic fungous infections in 1961. A symposium. Arch Intern Med. 1961 Aug;108:292–316. doi: 10.1001/archinte.1961.03620080124013. [DOI] [PubMed] [Google Scholar]

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