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The degree of SERT-mediated clearance decreases with increasing extracellular 5-HT. (A) A plot of the % inhibition of clearance induced by 1 μM paroxetine as a function of extracellular 5-HT. (B) A plot of the % inhibition of clearance induced by 1 μM paroxetine as a function of the log [exogenously added 5-HT] reveals a logarithmic relationship: as the exogenously added 5-HT increases, the proportion of clearance mediated by SERT decreases.
