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. 1968 Apr;95(4):1368–1374. doi: 10.1128/jb.95.4.1368-1374.1968

Constitutive Penicillinase Formation in Staphylococcus aureus Owing to a Mutation Unlinked to the Penicillinase Plasmid

Sidney Cohen 1, Helen M Sweeney 1
PMCID: PMC315095  PMID: 5646623

Abstract

Previously described penicillinase-constitutive mutations in Staphylococcus aureus are caused by genetic lesions in a regulator gene (or genes) on the penicillinase plasmid in close linkage to the structural gene. This report describes a new class (R2−) of penicillinase-constitutive mutants of S. aureus unlinked to the plasmid. By transductional analysis, the penicillinase plasmids in these mutants were wild type. Wild-type plasmids transduced into penicillinase-negative (plasmid loss) derivatives of R2− mutants produced penicillinase constitutively in amounts comparable to a fully induced culture of the wild-type strain. Penicillinase production in R2− mutants was maximal at 30 to 32 C and was much reduced at 40 C.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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