Abstract
Regulation of the synthesis and function of an l(+)-specific lactate-oxidizing enzyme system found in a homofermentative Streptococcus was investigated. With the exception of fructose, aerobic growth at the expense of a variety of substrates resulted in the formation of a lactate oxidation system; anaerobic growth resulted in a marked reduction or complete loss of lactate-oxidizing activity. Growth on fructose, under aerobic and anaerobic conditions, invariably produced a decrease in the activity of the lactate oxidation system. A negative control, activated by an early intermediate product of glycolysis, appeared to be responsible for repression of the lactate-oxidizing enzyme(s). The enzyme system confers upon the organism the ability to grow aerobically at the expense of l(+)-lactic acid.
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- BUYZE G., VAN DEN HAMER C. J., DE HAAN P. G. Correlation between hexosemonophosphate shunt, glycolytic system and fermentation-type in Lactobacilli. Antonie Van Leeuwenhoek. 1957;23(3-4):345–350. doi: 10.1007/BF02545886. [DOI] [PubMed] [Google Scholar]
- Gunsalus I. C., Umbreit W. W. The Oxidation of Glycerol by Streptococcus faecalis. J Bacteriol. 1945 Apr;49(4):347–357. doi: 10.1128/jb.49.4.347-357.1945. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HAGER L. P., GELLER D. M., LIPMANN F. Flavoprotein-catalyzed pyruvate oxidation in Lactobacillus delbrueckii. Fed Proc. 1954 Sep;13(3):734–738. [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- MAGASANIK B. Catabolite repression. Cold Spring Harb Symp Quant Biol. 1961;26:249–256. doi: 10.1101/sqb.1961.026.01.031. [DOI] [PubMed] [Google Scholar]
- SNOSWELL A. M. OXIDIZED NICOTINAMIDE-ADENINE DINUCLEOTIDE-INDEPENDENT LACTATE DEHYDROGENASES OF LACTOBACILLUS ARABINOSUS 17.5. Biochim Biophys Acta. 1963 Sep 3;77:7–9. doi: 10.1016/0006-3002(63)90464-5. [DOI] [PubMed] [Google Scholar]