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. 1968 Apr;95(4):1450–1460. doi: 10.1128/jb.95.4.1450-1460.1968

Deoxyribonucleic Acid Degradation in Bacillus subtilis During Exposure to Actinomycin D1

James L Farmer a
PMCID: PMC315106  PMID: 4967199

Abstract

At high concentrations (10 μg/ml), actinomycin D inhibited deoxyribonucleic acid (DNA) synthesis in Bacillus subtilis. Inhibition occurred quickly (in less than 1 min) and was complete. In strain 23 thy his, inhibition of DNA synthesis by actinomycin D was followed by partial degradation of one of the two daughter strands to acid-soluble products. Degradation began at the replication point and proceeded over a distance equal to about 12% of a chromosome in length. Actinomycin D played some essential part in degradation, since exposure of the cells to other treatments or agents which inhibit growth did not lead to the above result.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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