Abstract
Administration of Bordetella pertussis cell extracts induced in mice hypersensitivity to histamine, as well as pronounced leukocytosis and hypoglycemia. The leukocytosis was mainly caused by an increase in the small lymphocytes in the circulating blood, and it was most pronounced 3 to 4 days after injection of B. pertussis extracts. Rabbit antimouse lymphocyte serum produced a decrease in the lymphocyte count in normal mice, as well as in mice treated with B. pertussis extracts. This depression in lymphocytes was observed whether the antilymphocyte serum was given 1 day or 2 days after the administration of B. pertussis extracts. The increased histamine sensitivity and hypoglycemia of mice treated with B. pertussis extract were not affected by treatment with antilymphocyte serum, although a marked lymphopenia was present. These observations indicate that the three phenomena observed in pertussis-treated mice are independent of each other.
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Selected References
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- Gray J. G., Monaco A. P., Wood M. L., Russell P. S. Studies on heterologous anti-lymphocyte serum in mice. I. In vitro and in vivo properties. J Immunol. 1966 Feb;96(2):217–228. [PubMed] [Google Scholar]
- KIND L. S. The altered reactivity of mice after inoculation with Bordetella pertussis vaccine. Bacteriol Rev. 1958 Sep;22(3):173–182. doi: 10.1128/br.22.3.173-182.1958. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MORSE S. I. STUDIES ON THE LYMPHOCYTOSIS INDUCED IN MICE BY BORDETELLA PERTUSSIS. J Exp Med. 1965 Jan 1;121:49–68. doi: 10.1084/jem.121.1.49. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MUNOZ J., HESTEKIN B. M. Method of preparing histamine sensitizing factor. Nature. 1962 Dec 22;196:1192–1193. doi: 10.1038/1961192a0. [DOI] [PubMed] [Google Scholar]
- Munoz J., Bergman R. K. Histamine-sensitizing factors from microbial agents, with special reference to Bordetella pertussis. Bacteriol Rev. 1968 Jun;32(2):103–126. doi: 10.1128/br.32.2.103-126.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SZENTIVANYI A., FISHEL C. W., TALMAGE D. W. ADRENALINE MEDIATION OF HISTAMINE AND SEROTONIN HYPERGLYCEMIA IN NORMAL MICE AND THE ABSENCE OF ADRENALINE-INDUCED HYPERGLYCEMIA IN PERTUSSIS-SENSITIZED MICE. J Infect Dis. 1963 Sep-Oct;113:86–98. doi: 10.1093/infdis/113.2.86. [DOI] [PubMed] [Google Scholar]