Table 1.
Summary of profiled DLBCL cohorts
| Study cohort | DLBCL1 (training) | DLBCL2 (test) | DLBCL3 (test) | DLBCL4 (validation) |
|---|---|---|---|---|
| No. of patients | 233 | 181 | 131 | 147 |
| Specimen type | Frozen | Frozen | Frozen | FFPE |
| Study group | Multinational LLMPP | Multinational LLMPP | Multinational MMMLNP | Multinational |
| Therapy regimen | R-CHOP | CHOP | CHOP | R-CHOP |
| End point(s) and covariates | OS, IPI, COO | OS, IPI, COO | OS | PFS, OS, IPI |
| Median age, y (range) | 62 (17-92) | 65 (14-88) | 67 (8-93) | 57 (16-92) |
| IPI distribution, n (%) | ||||
| Low [0,1] | 75 (32) | 62 (34) | N/A | 56 (38) |
| Low int. [2] | 43 (18) | 45 (25) | 35 (24) | |
| High int. [3] | 30 (13) | 30 (17) | 37 (25) | |
| High [4,5] | 24 (10) | 23 (13) | 19 (13) | |
| COO, n (%) | ||||
| ABC-like | 93 (40) | 74 (41) | 50 (38) | N/A |
| GCB-like | 107 (46) | 76 (42) | 47 (36) | |
| Unclassified | 33 (14) | 31 (17) | 34 (26) | |
| Measurement platform | Affymetrix HG-U133 Plus 2.0 | Affymetrix HG-U133 Plus 2.0 | Affymetrix HG-U133A | ABI 7900HT TaqMan RT-PCR |
| Primary data source | NCBI GSE10846 | NCBI GSE10846 | NCBI GSE4475 | Present study |
| LMO2 probe set | 4005_at | 4005_at | 4005_at | Hs00277106_m1 |
| TNFRSF9 probe set | 3604_at | 3604_at | 3604_at | Hs00155512_m1 |
| Reference | Lenz et al, 200818 | Lenz et al, 200818Rosenwald et al, 200211 | Hummel et al, 200612 | 98 samples from Malumbres et al, 200819 |
LLMPP indicates Leukemia/Lymphoma Molecular Profiling Project; MMMLNP, Molecular Mechanisms in Malignant Lymphomas Network Project of the Deutsche Krebshilfe; COO, cell-of-origin classification; NCBI, National Center for Biotechnology Information; and GSE, Gene Expression Omnibus series.