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. 1969 Jun;98(3):1114–1119. doi: 10.1128/jb.98.3.1114-1119.1969

Biosynthesis of Riboflavine in Corynebacterium Species: the Purine Precursor

Charles M Baugh 1, Carlos L Krumdieck 1
PMCID: PMC315303  PMID: 5788699

Abstract

Corynebacterium species lacks the ability to convert either xanthine or guanine to adenine. This defect and the use of the purine nucleoside antibiotic decoyinine, which blocks the conversion of xanthosine monophosphate → guanosine monophosphate, permit an experimental design in which the interconversion of purines is largely prevented. Cultures of this organism were grown in the presence of decoyinine and various purine supplements. Data obtained by comparing the radioactivity incorporated from guanine-2-14C or xanthine-2-14C into bacterial guanine, xanthine, and riboflavine indicate that guanine or a close derivative of guanine is the purine precursor of riboflavine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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