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. 1969 Oct;100(1):370–376. doi: 10.1128/jb.100.1.370-376.1969

Differential Effect of Respiratory Inhibitors on Ergosterol Synthesis by Saccharomyces cerevisiae During Adaptation to Oxygen

B G Adams a,1, L W Parks a
PMCID: PMC315402  PMID: 5344101

Abstract

The effect of different respiratory inhibitors on the ergosterol content of microaerobically grown non-proliferating yeast cultures was monitored during adaptation to oxygen. It was found that dinitrophenol, azide, and cyanide, which act on the mechanism of the respiratory chain, cause a marked stimulation of sterol production. Acriflavine and chloramphenicol, which affect the synthesis of the respiratory apparatus, caused a delay in the onset of ergosterol synthesis or a marked decrease in sterol content. The data obtained provide presumptive evidence that a component of sterol formation is synthesized on the 70S ribosomal system of the mitochondrion and induced in the presence of oxygen.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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