Skip to main content
NCBI home page
Journal of Bacteriology logoLink to Journal of Bacteriology
. 1965 Jan;89(1):17–22. doi: 10.1128/jb.89.1.17-22.1965

Changes in Mouse Pneumonitis Agent Associated with Development of Resistance to Chlortetracycline

James W Moulder 1, Dorothy L Novosel 1, Ilse I E Tribby 1
PMCID: PMC315542  PMID: 14255660

Abstract

Moulder, James W. (University of Chicago, Chicago, Ill.), Dorothy L. Novosel, and Ilse I. E. Tribby. Changes in mouse pneumonitis agent associated with development of resistance to chlortetracycline. J. Bacteriol. 89:17–22. 1965.—A chlortetracycline-resistant mutant of mouse pneumonitis agent, a member of the psittacosis group of microorganisms, differed in several ways from the susceptible stock from which it had been derived by serial chick-embryo passage in the presence of the antibiotic. It was almost completely resistant to chlortetracycline, had a longer growth cycle, produced many more very large particles, was not neutralized by parent antiserum and vice versa, was 10 times as resistant to d-cycloserine, and was highly lethal to mice when inoculated intracerebrally. These changes probably do not occur independently of one another but are the reflection of some genetically controlled change in the surface structure of the mouse pneumonitis particle which enables the resistant mutant to multiply in the presence of chlortetracycline.

Full text

PDF
17

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. FRANKLIN T. J. The inhibition of incorporation of leucine into protein of cell-free systems from rat liver and Escherichia coli by chlortetracycline. Biochem J. 1963 Jun;87:449–453. doi: 10.1042/bj0870449. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. GORDON F. B., ANDREW V. W., WAGNER J. C. Development of resistance to penicillin and to chlortetracycline in psittacosis virus. Virology. 1957 Aug;4(1):156–171. doi: 10.1016/0042-6822(57)90051-x. [DOI] [PubMed] [Google Scholar]
  3. GREENLAND R. M., MOULDER J. W. A search for genetic interaction in the psittacosis group. J Infect Dis. 1961 May-Jun;108:293–303. doi: 10.1093/infdis/108.3.293. [DOI] [PubMed] [Google Scholar]
  4. GREENLAND R. M., MOULDER J. W. The development of resistance to a quinoxaline N-oxide in feline pneumonitis virus. J Infect Dis. 1958 May-Jun;102(3):294–299. doi: 10.1093/infdis/102.3.294. [DOI] [PubMed] [Google Scholar]
  5. LITWIN J., OFFICER J. E., BROWN A., MOULDER J. W. A comparative study of the growth cycles of different members of the psittacosis group in different host cells. J Infect Dis. 1961 Nov-Dec;109:251–279. doi: 10.1093/infdis/109.3.251. [DOI] [PubMed] [Google Scholar]
  6. Laskin A. I., May Chan W. Inhibition by tetracyclines of polyuridylic acid directed phenylalanine incorporation in Escherichia coli cell-free systems. Biochem Biophys Res Commun. 1964;14:137–142. doi: 10.1016/0006-291x(64)90243-8. [DOI] [PubMed] [Google Scholar]
  7. MOULDER J. W., McCORMACK B. R., GOGOLAK F. M., ZEBOVITZ M. M., ITATANI M. K. Production and properties of a penicillinresistant strain of feline pneumonitis virus. J Infect Dis. 1955 Jan-Feb;96(1):57–74. doi: 10.1093/infdis/96.1.57. [DOI] [PubMed] [Google Scholar]
  8. MOULDER J. W., NOVOSEL D. L., OFFICER J. E. INHIBITION OF THE GROWTH OF AGENTS OF THE PSITTACOSIS GROUP BY D-CYCLOSERINE AND ITS SPECIFIC REVERSAL BY D-ALANINE. J Bacteriol. 1963 Mar;85:707–711. doi: 10.1128/jb.85.3.707-711.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. MOULDER J. W., RUDA J., COLON J. I., GREENLAND R. M. The effect of passage with chloramphenicol upon the behavior of penicillin-resistant feline pneumonitis virus during subsequent passage with penicillin. J Infect Dis. 1958 Mar-Apr;102(2):186–201. doi: 10.1093/infdis/102.2.186. [DOI] [PubMed] [Google Scholar]
  10. MOULDER J. W., RUDA J., GREENLAND R. M. Separation of mixtures of two drugresistant strains of feline pneumonitis virus by limiting dilution passage in chick embryo yolk sac. J Infect Dis. 1958 Sep-Oct;103(2):172–177. doi: 10.1093/infdis/103.2.172. [DOI] [PubMed] [Google Scholar]
  11. MOULDER J. W., WEISS E. Purification and properties of the agent of feline pneumonitis. J Infect Dis. 1951 Jan-Feb;88(1):56–67. doi: 10.1093/infdis/88.1.56. [DOI] [PubMed] [Google Scholar]
  12. ROTEM Z. Isolation of a variant strain of psittacosis virus after serial passages via the respiratory route in mice. J Infect Dis. 1962 Nov-Dec;111:184–191. doi: 10.1093/infdis/111.3.184. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Bacteriology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES