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. 1965 Jan;89(1):154–158. doi: 10.1128/jb.89.1.154-158.1965

Host-Parasite Relationships Among Group A Streptococci III. Depression of Reticuloendothelial Function by Streptococcal Pyrogenic Exotoxins

Edgar E Hanna a, Dennis W Watson a,1
PMCID: PMC315563  PMID: 14255656

Abstract

Hanna, Edgar E. (University of Minnesota, Minneapolis), and Dennis W. Watson. Host-parasite relationships among group A streptococci. III. Depression of reticuloendothelial function by streptococcal pyrogenic exotoxins. J. Bacteriol. 89:154–158. 1965.—Measurement of the rate of clearance of colloidal carbon from the circulating blood is an effective and simple technique for assessing the functional state of the reticuloendothelial system (RES) of experimental animals. This paper concerns a study of the RES function in rabbits after treatment with streptococcal pyrogenic exotoxins. Intravenous injection of 1.0 ml of the toxin produced by a strain of type 18, group A streptococcus caused a prolonged (at least 24 hr) depression of RES function. The activity at 48 hr after toxin injection was about equal to that in control animals. Repeated intravenous injections of the toxin abolished the initial depressing effect on RES function, but did not cause stimulation. In comparison, intravenous injection of equivalent doses of endotoxin prepared from Escherichia coli COO8 also caused an initial depression of RES function; however, in contrast with the effect of exotoxin, stimulation occurred as early as 24 hr and was about twice as active at 48 hr. The prolonged depression by streptococcal pyrogenic exotoxin is suggested as one means by which this toxin potentiates lethality and tissue damage by other toxins such as streptolysin O and endotoxins from gram-negative bacteria.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BENACERRAF B., SEBESTYEN M. M. Effect of bacterial endotoxins on the reticuloendothelial system. Fed Proc. 1957 Sep;16(3):860–867. [PubMed] [Google Scholar]
  2. BENACERRAF B., THORBECKE G. J., JACOBY D. Effect of zymosan on endotoxin toxicity in mice. Proc Soc Exp Biol Med. 1959 Apr;100(4):796–799. doi: 10.3181/00379727-100-24781. [DOI] [PubMed] [Google Scholar]
  3. BIOZZI G., BENACERRAF B., HALPERN B. N. The effect of Salm. typhi and its endotoxin on the phagocytic activity of the reticuloendothelial system in mice. Br J Exp Pathol. 1955 Jun;36(3):226–235. [PMC free article] [PubMed] [Google Scholar]
  4. CREMER N., WATSON D. W. Host-parasite factors in group A streptococcal infections. A comparative study of streptococcal pyrogenic toxins and gram-negative bacterial endotoxin. J Exp Med. 1960 Dec 1;112:1037–1053. doi: 10.1084/jem.112.6.1037. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. FREEDMAN H. H. Reticuloendothelial system and passive transfer of endotoxin tolerance. Ann N Y Acad Sci. 1960 Jun;88:99–106. [PubMed] [Google Scholar]
  6. HALPERN B. N., BENACERRAF B., BIOZZI G. Quantitative study of the granulopectic activity of the reticulo-endothelial system. I. The effect of the ingredients present in India ink and of substances affecting blood clotting in vivo on the fate of carbon particles administered intravenously in rats, mice and rabbits. Br J Exp Pathol. 1953 Aug;34(4):426–440. [PMC free article] [PubMed] [Google Scholar]
  7. HOWARD J. G., BIOZZI G., HALPERN B. N., STIFFEL C., MOUTON D. The effect of Mycobacterium tuberculosis (BCG) infection on the resistance of mice to bacterial endotoxin and Salmonella enteritidis infection. Br J Exp Pathol. 1959 Jun;40(3):281–290. [PMC free article] [PubMed] [Google Scholar]
  8. HOWARD J. G., ROWLEY D., WARDLAW A. C. Investigations on the mechanism of stimulation of non-specific immunity by bacterial lipopolysaccharides. Immunology. 1958 Jul;1(3):181–203. [PMC free article] [PubMed] [Google Scholar]
  9. JENKIN C. R., ROWLEY D. The role of opsonins in the clearance of living and inert particles by cells of the reticuloendothelial system. J Exp Med. 1961 Sep 1;114:363–374. doi: 10.1084/jem.114.3.363. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. ROWLEY D. The role of opsonins in non-specific immunity. J Exp Med. 1960 Jan 1;111:137–144. doi: 10.1084/jem.111.1.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. SCHAEDLER R. W., DUBOS R. J. The susceptibility of mice to bacterial endotoxins. J Exp Med. 1961 Mar 1;113:559–570. doi: 10.1084/jem.113.3.559. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. SCHWAB J. H., WATSON D. W., CROMARTIE W. J. Production of generalized Shwartzman reaction with group A streptococcal factors. Proc Soc Exp Biol Med. 1953 Apr;82(4):754–761. doi: 10.3181/00379727-82-20237. [DOI] [PubMed] [Google Scholar]
  13. STUART A. E., COOPER G. N. Susceptibility of mice to bacterial endotoxin after modification of reticulo-endothelial function by simple lipids. J Pathol Bacteriol. 1962 Jan;83:245–254. doi: 10.1002/path.1700830126. [DOI] [PubMed] [Google Scholar]
  14. WATSON D. W., KIM Y. B. MODIFICATION OF HOST RESPONSES TO BACTERIAL ENDOTOXINS. I. SPECIFICITY OF PYROGENIC TOLERANCE AND THE ROLE OF HYPERSENSITIVITY IN PYROGENICITY, LETHALITY, AND SKIN REACTIVITY. J Exp Med. 1963 Sep 1;118:425–446. doi: 10.1084/jem.118.3.425. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. WOOLES W. R., DILUZIO N. R. RETICULOENDOTHELIAL FUNCTION AND THE IMMUNE RESPONSE. Science. 1963 Nov 22;142(3595):1078–1080. doi: 10.1126/science.142.3595.1078. [DOI] [PubMed] [Google Scholar]

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