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Vandetanib co-treatment blocked l-dopa-induced angiogenic activity in the basal ganglia. Endothelial proliferation (BrdU+/Laminin+ cells) (A), nestin upregulation (B), downregulation of endothelial barrier antigen (EBA; C), and parenchymal albumin extravasation (D). l-dopa + vehicle (n = 12), l-dopa + vandetanib (n = 10), saline (n = 12). One-factor ANOVA followed by post hoc Student–Newman–Keul’s. P < 0.05 *versus saline controls, # versus l-dopa + vandetanib.
