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. 1965 Nov;90(5):1448–1454. doi: 10.1128/jb.90.5.1448-1454.1965

Detection of Viruslike Particles in Germ-Free Mice

Masahiro Kajima 1, Morris Pollard 1
PMCID: PMC315834  PMID: 4284971

Abstract

Kajima, Masahiro (University of Notre Dame, Notre Dame, Ind.), and Morris Pollard. Detection of viruslike particles in germ-free mice. J. Bacteriol. 90:1448–1454. 1965.—Viruslike particles similar in structure to the mouse leukemia agent were detected by electron microscopy in thymus tissues of germ-free AK mice which had developed spontaneous leukemia. In addition, unique viruslike particles (type B) were detected in tissues from spontaneous mammary adenocarcinoma of germ-free C3H mice. Leukemia virus-like particles were also observed in the thymuses of the control AK mice and of the C3H control mice as well as of those with mammary tumors. Germ-free mice are not virus-free. The routes of transmission of leukemia as well as of mammary tumor viruses may be “vertical,” through the embryo or placenta.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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