Abstract
Pittillo, Robert F. (Southern Research Institute, Birmingham, Ala.), Mary Lucas, Robert T. Blackwell, and Carolyn Woolley. Modification of radiation damage of bacteria by folic acid antagonists. J. Bacteriol. 90:1548–1551. 1965.—The folic acid analogues, 2,4-diamino-6-methylpteridine, amethopterin, and aminopterin, have been found to sensitize certain bacteria, especially Escherichia coli, to the lethal action of ionizing irradiation. Data are presented which indicate that (i) the compounds must be present during the irradiation period for maximal sensitization to be observed, (ii) the sensitizing effect can be nullified by cysteine or cysteamine, (iii) the sensitizing effect occurs in a number of diverse bacterial genera, and (iv) folic acid neither sensitizes bacteria to irradiation nor prevents the sensitization caused by these antifolic agents.
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Selected References
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- BAGSHAW M. A. Approaches for combined radiation and chemotherapy. Laval Med. 1963 Jan;34:124–133. [PubMed] [Google Scholar]
- HILL R. F. A radiation-sensitive mutant of Escherichia coli. Biochim Biophys Acta. 1958 Dec;30(3):636–637. doi: 10.1016/0006-3002(58)90112-4. [DOI] [PubMed] [Google Scholar]
- MAISIN H. CHIMIOTH'ERAPIE ANTICANC'EREUSE ET RADIOSENSIBILISATION. J Belge Radiol. 1963;46:391–426. [PubMed] [Google Scholar]
- PITTILLO R. F., LUCAS M., WOOLLEY C., BLACKWELL R. T., MONCRIEF C. SPARSOMYCIN MODIFICATION OF THE LETHAL ACTION OF IONIZING IRRADIATION ON ESCHERICHIA COLI. Nature. 1965 Feb 20;205:773–776. doi: 10.1038/205773a0. [DOI] [PubMed] [Google Scholar]
- PITTILLO R. F., NARKATES A. J., BURNS J. MICROBIOLOGICAL EVALUATION OF 1,3-BIS (2-CHLOROETHYL)-I-NITROSOUREA. Cancer Res. 1964 Aug;24:1222–1228. [PubMed] [Google Scholar]
- SCHABEL F. M., Jr, PITTILLO R. F. Screening for and biological characterization of antitumor agents using microorganisms. Adv Appl Microbiol. 1961;3:223–256. doi: 10.1016/s0065-2164(08)70511-2. [DOI] [PubMed] [Google Scholar]