Skip to main content
NCBI home page
Journal of Bacteriology logoLink to Journal of Bacteriology
. 1966 Jan;91(1):422–427. doi: 10.1128/jb.91.1.422-427.1966

Patterns of Human Antibody Reactions in Coccidioidomycosis1

Y Sawaki 1,2, M Huppert 1,2, J W Bailey 1,2, Y Yagi 1,2
PMCID: PMC315963  PMID: 5903107

Abstract

Sawaki, Y. (Veterans Administration Hospital, San Fernando, Calif.), M. Huppert, J. W. Bailey, and Y. Yagi. Patterns of human antibody reactions in coccidioidomycosis. J. Bacteriol. 91:422–427. 1966.—At least two antigen-antibody systems in coccidioidomycosis have been demonstrated by immunodiffusion and immunoelectrophoresis, including the use of I131-coccidioidin. Sera which were positive in the conventional complement-fixation (CF) test, but negative in the tube precipitin (TP) test, yielded only one line of precipitate in the immunodiffusion test. In immunoelectrophoresis, also, there was only one precipitate arc which appeared in the γ2-globulin region. On the other hand, sera which were positive in both CF and TP tests yielded two different lines in the immunodiffusion test. In immunoelectrophoresis, also, there were two precipitate arcs: one in the γ2-globulin region and the other in the γ1-globulin area. Radioimmunoelectrophoresis demonstrated that the antibody activity in IG-G globulin, roughly parallels the CF titer. A similar correlation existed between the IG-M antibody activity and the TP reactivity. Antibody activity was present in the IG-A globulin but it did not reflect either CF or TP activity.

Full text

PDF
422

Images in this article

423Image
on p.423
424Image
on p.424
424Image
on p.424
424Image
on p.424

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. HUNTER W. M., GREENWOOD F. C. Preparation of iodine-131 labelled human growth hormone of high specific activity. Nature. 1962 May 5;194:495–496. doi: 10.1038/194495a0. [DOI] [PubMed] [Google Scholar]
  2. PAPPAGIANIS D., LINDSEY N. J., SMITH C. E., SAITO M. T. ANTIBODIES IN HUMAN COCCIDIOIDOMYCOSIS: IMMUNOELECTROPHORETIC PROPERTIES. Proc Soc Exp Biol Med. 1965 Jan;118:118–122. doi: 10.3181/00379727-118-29773. [DOI] [PubMed] [Google Scholar]
  3. PAPPAGIANIS D., SMITH C. E., KOBAYASHI G. S., SAITO M. T. Studies of antigens from young mycelia of Coccidioides immitis. J Infect Dis. 1961 Jan-Feb;108:35–44. doi: 10.1093/infdis/108.1.35. [DOI] [PubMed] [Google Scholar]
  4. SMITH C. E., SAITO M. T., BEARD R. R., KEPP R. M., CLARK R. W., EDDIE B. U. Serological tests in the diagnosis and prognosis of coccidioidomycosis. Am J Hyg. 1950 Jul;52(1):1–21. doi: 10.1093/oxfordjournals.aje.a119404. [DOI] [PubMed] [Google Scholar]
  5. SMITH C. E., SAITO M. T., SIMONS S. A. Pattern of 39,500 serologic tests in coccidioidomycosis. J Am Med Assoc. 1956 Feb 18;160(7):546–552. doi: 10.1001/jama.1956.02960420026008. [DOI] [PubMed] [Google Scholar]
  6. YAGI Y., MAIER P., PRESSMAN D., ARBESMAN C. E., REISMAN R. E., LENZNER A. R. MULTIPLICITY OF INSULIN-BINDING ANTIBODIES IN HUMAN SERA. PRESENCE OF ANTIBODY ACTIVITY IN GAMMA-, BETA-2A-, AND BETA-2M-GLOBULINS. J Immunol. 1963 May;90:760–769. [PubMed] [Google Scholar]
  7. YAGI Y., MAIER P., PRESSMAN D., ARBESMAN C. E., REISMAN R. E. THE PRESENCE OF THE RAGWEED-BINDING ANTIBODIES IN THE BETA-2A, BETA-2M, AND GAMMA GLOBULINS OF THE SENSITIVE INDIVIDUALS. J Immunol. 1963 Jul;91:83–89. [PubMed] [Google Scholar]

Articles from Journal of Bacteriology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES