Abstract
Forsyth, Ben R. (National Institute of Allergy and Infectious Diseases, Bethesda, Md.), Helen V. Coates, and Robert M. Chanock. Biophysical studies of respiratory syncytial virus. II. Identification of two soluble complement-fixing antigens of respiratory syncytial virus. J. Bacteriol. 91:1270–1276. 1966.—Column chromatography of concentrated preparations was used to separate two antigenic components from the “soluble complement-fixing (CF) antigen” of respiratory syncytial (RS) virus. These antigens, designated antigen A and antigen B, stimulated homologous but not heterologous CF antibodies. Only antigen A stimulated the production of neutralizing antibody in guinea pigs. There was a dissociation between the CF and neutralizing antibody responses of guinea pigs immunized with antigen A. The two antigens were shown to have different molecular size, density, and sensitivity to lipolytic agents. Both antigens appeared to be components of the RS viral particle. Serological studies demonstrated that both antigens were formed during RS virus infection of children and adults.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BEEM M., WRIGHT F. H., HAMRE D., EGERER R., OEHME M. Association of the chimpanzee coryza agent with acute respiratory disease in children. N Engl J Med. 1960 Sep 15;263:523–530. doi: 10.1056/NEJM196009152631101. [DOI] [PubMed] [Google Scholar]
- CHANOCK R. M., KIM H. W., VARGOSKO A. J., DELEVA A., JOHNSON K. M., CUMMING C., PARROTT R. H. Respiratory syncytial virus. I. Virus recovery and other observations during 1960 outbreak of bronchiolitis, pneumonia, and minor respiratory diseases in children. JAMA. 1961 May 27;176:647–653. [PubMed] [Google Scholar]
- CHANOCK R., FINBERG L. Recovery from infants with respiratory illness of a virus related to chimpanzee coryza agent (CCA). II. Epidemiologic aspects of infection in infants and young children. Am J Hyg. 1957 Nov;66(3):291–300. doi: 10.1093/oxfordjournals.aje.a119902. [DOI] [PubMed] [Google Scholar]
- CHANOCK R., ROIZMAN B., MYERS R. Recovery from infants with respiratory illness of a virus related to chimpanzee coryza agent (CCA). I. Isolation, properties and characterization. Am J Hyg. 1957 Nov;66(3):281–290. doi: 10.1093/oxfordjournals.aje.a119901. [DOI] [PubMed] [Google Scholar]
- Coates H. V., Forsyth B. R., Chanock R. M. Biophysical studies of respiratory syncytial virus. I. Density of respiratory syncytial virus and associated complement-fixing antigens in cesium chloride density gradient. J Bacteriol. 1966 Mar;91(3):1263–1269. doi: 10.1128/jb.91.3.1263-1269.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HUEBNER R. J., CHANOCK R. M., RUBIN B. A., CASEY M. J. INDUCTION BY ADENOVIRUS TYPE 7 OF TUMORS IN HAMSTERS HAVING THE ANTIGENIC CHARACTERISTICS OF SV40 VIRUS. Proc Natl Acad Sci U S A. 1964 Dec;52:1333–1340. doi: 10.1073/pnas.52.6.1333. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KISCH A. L., JOHNSON K. M., CHANOCK R. M. Immunofluorescence with respiratory syncytial virus. Virology. 1962 Feb;16:177–189. doi: 10.1016/0042-6822(62)90293-3. [DOI] [PubMed] [Google Scholar]
- SCHAFER W. Structure of some animal viruses and significance of their components. Bacteriol Rev. 1963 Mar;27:1–17. doi: 10.1128/br.27.1.1-17.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SEVER J. L. Application of a microtechnique to viral serological investigations. J Immunol. 1962 Mar;88:320–329. [PubMed] [Google Scholar]
- WATERSON A. P., HOBSON D. Relationship between respiratory syncytial virus and Newcastle disease-parainfluenza group. Br Med J. 1962 Nov 3;2(5313):1166–1167. doi: 10.1136/bmj.2.5313.1166. [DOI] [PMC free article] [PubMed] [Google Scholar]