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Thrombin-stimulated extracellular calcium influx is mediated by L-type Ca2+ channel activity. (A) Representative Fura-2 radiometric tracings of [Ca2+]i in WT SMCs after treatment with thrombin in the presence or absence of nifedipine. Arrow indicates time of thrombin addition. (B) Summary data showing the effect of nifedipine on thrombin-stimulated [Ca2+]i (thrombin, n=14 cells; thrombin + nifedipine, n=30 cells). * P<0.05 vs. thrombin.
