Abstract
Zampieri, Antonio (Palo Alto Medical Research Foundation, Palo Alto, Calif.), and Joseph Greenberg. Radiomimetic properties of 2-aminopurine in Escherichia coli. J. Bacteriol. 91:1773–1774. 1966.—A radioresistant mutant (R4) of Escherichia coli strain S was found to be resistant to 2-aminopurine. The composition of the post-treatment plating medium and temperature of incubation did not influence the sensitivity of R4 to 2-aminopurine. However, strain S was much more sensitive to 2-aminopurine when plated on tryptone-agar than on minimal glucose-salts-agar. Strain S was also more sensitive when the post-treatment incubation was at 37 C than at 45 C. When E. coli strain S was treated with sufficient 2-aminopurine to permit only 10−5 survivors, 67% of the survivors were resistant to ultraviolet light and to radiomimetic compounds. 2-Aminopurine induced filaments in radiation-sensitive, but not radiation-resistant, strains of E. coli. It is concluded that 2-aminopurine, a base analogue which induces transition mutations, is radiomimetic in several properties.
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Selected References
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- CURRY J., GREENBERG J. Filament formation in radio-resistant mutants of Escherichia coli S after treatment with ultraviolet light and radiomimetic agents. J Bacteriol. 1962 Jan;83:38–42. doi: 10.1128/jb.83.1.38-42.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]
- TERAWAKI A., GREENBERG J. EFFECT OF SOME RADIOMIMETIC AGENTS ON DEOXYRIBONUCLEIC ACID SYNTHESIS IN ESCHERICHIA COLI AND TRANSFORMATION IN BACILLUS SUBTILIS. Biochim Biophys Acta. 1965 Jan 11;95:170–173. doi: 10.1016/0005-2787(65)90221-2. [DOI] [PubMed] [Google Scholar]
- WOODY-KARRER P., GREENBERG J. RESISTANCE AND CROSS RESISTANCE OF ESCHERICHIA COLI S MUTANTS TO THE RADIOMIMETIC AGENT NITROFURAZONE. J Bacteriol. 1963 Jun;85:1208–1216. doi: 10.1128/jb.85.6.1208-1216.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ZAMPIERI A., GREENBERG J. EFFECT OF HEAT AND PLATING MEDIUM ON SURVIVAL OF ESCHERICHIA COLI AFTER TREATMENT WITH RADIOMIMETIC CHEMICALS. J Bacteriol. 1965 Apr;89:931–936. doi: 10.1128/jb.89.4.931-936.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zampieri A., Greenberg J. Cross-resistance relationships in Escherichia coli between ultraviolet radiation and nitrous acid. J Bacteriol. 1964 May;87(5):1094–1099. doi: 10.1128/jb.87.5.1094-1099.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]