Skip to main content
NCBI home page
Journal of Bacteriology logoLink to Journal of Bacteriology
. 1966 Jun;91(6):2169–2174. doi: 10.1128/jb.91.6.2169-2174.1966

Endotoxin-Induced Hypersensitivity to Histamine in Mice I. Contrasting Effects of Bacterial Lipopolysaccharides and the Classical Histamine-Sensitizing Factor of Bordetella pertussis

Robert E Pieroni 1, Edward J Broderick 1, Leo Levine 1
PMCID: PMC316189  PMID: 5943934

Abstract

Pieroni, Robert E. (Massachusetts Department of Public Health, Boston), Edward J. Broderick, and Leo Levine. Endotoxin-induced hypersensitivity to histamine in mice. I. Contrasting effects of bacterial lipopolysaccharides and the classical histamine-sensitizing factor of Bordetella pertussis. J. Bacteriol. 91:2169–2174. 1966.—The capacity of typhoid and possibly of pertussis endotoxins to induce histamine-shock susceptibility in some of the mice that survive graded doses of these endotoxins was confirmed. It was demonstrated, however, that pertussis endotoxin cannot be the main source of the typical histamine sensitization of pertussis vaccine. The following points are made. (i) With typhoid and pertussis endotoxins as inducers of histamine shock, no systematic relation between deaths and induction dose could be found, and 100% mortality could not be achieved. In contrast, with pertussis protective fraction as inducer, there was clear dose-response regression, with 100% mortality possible. (ii) The major part of the histamine-sensitizing activity of pertussis vaccine or its extracts was destroyed by trypsinization or by heating for 30 min at 100 C. These processes do not affect the histamine-sensitizing activity of the endotoxins. The implication for purified pertussis vaccine with high histamine-sensitization capacity is that endotoxin need not necessarily be present. The significance and possible mechanisms of action of endotoxin-induced histamine sensitivity are briefly discussed.

Full text

PDF
2169

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BERGMAN R. K., MUNOZ J. CIRCULATORY COLLAPSE IN ANAPHYLAXIS AND HISTAMINE TOXICITY IN MICE. J Immunol. 1965 Jul;95:1–8. [PubMed] [Google Scholar]
  2. FISHEL C. W., SZENTIVANYI A., TALMAGE D. W. Sensitization and desensitization of mice to histamine and serotonin by neurohumors. J Immunol. 1962 Jul;89:8–18. [PubMed] [Google Scholar]
  3. JOO I., PUSZTAI Z. Interconnexion between the protective antigen and the histamine-sensitizing factor of Bordetella pertussis. Nature. 1960 Oct 22;188:331–332. doi: 10.1038/188331b0. [DOI] [PubMed] [Google Scholar]
  4. KIND L. S. Effects of heat on the sensitizing and shocking properties of Hemophilus pertussis. J Immunol. 1956 Aug;77(2):115–118. [PubMed] [Google Scholar]
  5. KIND L. S. The altered reactivity of mice after immunization with Hemophilus pertussis vaccine. J Immunol. 1953 Apr;70(4):411–420. [PubMed] [Google Scholar]
  6. MAITLAND H. B., KOHN R., MACDONALD A. D. The histamine-sensitizing property of Haemophilus pertussis. J Hyg (Lond) 1955 Jun;53(2):196–211. doi: 10.1017/s0022172400000668. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. MALKIEL S., HARGIS B. J. ANAPHYLACTIC REACTIONS IN MICE INDUCED BY BORDETELLA PERTUSSIS LIPOPOLYSACCHARIDE. J Allergy. 1964 Jul-Aug;35:306–312. doi: 10.1016/0021-8707(64)90093-0. [DOI] [PubMed] [Google Scholar]
  8. MUNOZ J. J. SYMPOSIUM ON RELATIONSHIP OF STRUCTURE OF MICROORGANISMS TO THEIR IMMUNOLOGICAL PROPERTIES. I. IMMUNOLOGICAL AND OTHER BIOLOGICAL ACTIVITIES OF BORDETELLA PERTUSSIS ANTIGENS. Bacteriol Rev. 1963 Dec;27:325–340. doi: 10.1128/br.27.4.325-340.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. MUNOZ J. Permeability changes produced in mice by Bordetella pertussis. J Immunol. 1961 Jun;86:618–626. [PubMed] [Google Scholar]
  10. NIWA M. Histamine sensitizing factor of Bordetella pertussis. J Biochem. 1962 Mar;51:222–230. doi: 10.1093/oxfordjournals.jbchem.a127524. [DOI] [PubMed] [Google Scholar]
  11. PITTMAN M. Comparison of the histamine sensitizing property with the protective activity of pertussis vaccines for mice. J Infect Dis. 1951 Nov-Dec;89(3):300–304. doi: 10.1093/infdis/89.3.300. [DOI] [PubMed] [Google Scholar]
  12. PRESTON N. W. Factors influencing the assay of the histamine-sensitising factor of Haemophilus pertussis. J Pathol Bacteriol. 1959 Jul;78:217–224. [PubMed] [Google Scholar]
  13. Pieroni R. E., Broderick E. J., Levine L. The soluble protective antigen and the histamine-sensitizing factor of Bordetella pertussis. J Immunol. 1965 Oct;95(4):643–650. [PubMed] [Google Scholar]
  14. SCHAYER R. W., GANLEY O. H. Relationship of increased histidine decarboxylase activity to Bordetella pertussis vaccine sensitization of mice. J Allergy. 1961 May-Jun;32:204–213. doi: 10.1016/0021-8707(61)90049-1. [DOI] [PubMed] [Google Scholar]
  15. SCHUCHARDT L. F., MUNOZ J., VERWEY W. F., SAGIN J. F. THE RELATIONSHIP OF AGGLUTINOGEN TO OTHER ANTIGENS OF BORDETELLA PERTUSSIS. J Immunol. 1963 Jul;91:107–111. [PubMed] [Google Scholar]
  16. VAN HEMERT, VAN WEZELA, COHEN H. H. PREPARATION OF SOLUBLE PERTUSSIS VACCINE. Nature. 1964 Aug 15;203:774–775. doi: 10.1038/203774a0. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Bacteriology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES