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. 2011 Jun 13;26(5):629–635. doi: 10.1093/mutage/ger024

Table III.

Fold increase AUC4–96 h for CYP1A1 gene expression compared to solvent control

Exposure groups % of BP alone CYP1A1 Expression fold increase vs unexposed cells AUC4–96 h (mean ± range, n=2)a CYP1A1 Expression AUC fold increase/h
1 μM BP 100 6257 ± 2604 68.0
1 μM BP + 1 μM TMS 277 17416 ± 11141 189.3
1 μM BP + 4 μM TMS 1038 58972 ± 15394a 641.0
a

CYP1A1 AUC4–96 h values from cells exposed to BP + 1 μM TMS were not different from cells exposed to BP alone (P = 0.343 by Mann–Whitney rank sum test). However, CYP1A1 AUC4–96 h values from cells exposed to BP + 4 μM TMS were significantly different from cells exposed to BP alone (P = 0.004 by Mann–Whitney rank sum test).