Abstract
Kawakami, Masaya (Gunma University, Maebashi, Japan), Nobutaka Osawa, and Susumu Mitsuhashi. Experimental salmonellosis. VII. Comparison of the immunizing effect of live vaccine and materials extracted from Salmonella enteritidis. J. Bacteriol. 92:1585–1589. 1966.—Attempts were made to isolate the factors of live vaccine which immunize against Salmonella enteritidis infection in mice. Some effective substances were found in cellular extracts of this organism when those extracts were prepared by mild procedures. One of these substances was a heat-labile toxin (toxin L), which was found in an earlier study to be homogeneous as evidenced by chromatographic, ultracentrifugal, and serological analyses and which was phospholipoprotein in nature. Mice immunized with “toxin L” were protected against a 10 MLD challenge infection with a virulent strain to the same extent as animals immunized with live vaccine of an attenuated strain, SER. However, no agglutinin could be detected in sera of the animals given “toxin L.” Another effective substance, endotoxin, a heat-stable toxin, which was extracted from the same organisms, demonstrated poor protective effect. Possible mechanisms of immunization with live vaccine in S. enteritidis infection in mice are discussed.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- HOBSON D. Resistance to reinfection in experimental mouse typhoid. J Hyg (Lond) 1957 Sep;55(3):334–343. doi: 10.1017/s0022172400037244. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KAWAKAMI M., MITSUHASHI S. EXPERIMENTAL SALMONELLOSIS. IV. LIPID CONTENT OF TOXIN L OBTAINED FROM SALMONELLA ENTERITIDIS. J Bacteriol. 1965 Jan;89:193–197. doi: 10.1128/jb.89.1.193-197.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KAWAKAMI M., OSAWA N., MITSUHASHI S. EXPERIMENTAL SALMONELLOSIS. III. NEW TOXIC FRACTION (L) OBTAINED FROM SALMONELLA ENTERITIDIS AND ITS IMMUNOLOGICAL PROPERTIES. J Bacteriol. 1963 Oct;86:872–879. doi: 10.1128/jb.86.4.872-879.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MACLEOD D. R. Immunity to Salmonella infection in mice. J Hyg (Lond) 1954 Mar;52(1):9–17. doi: 10.1017/s0022172400027200. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MITSUHASHI S., HARADA K., KAWAKAMI M. Studies on the experimental typhoid. II. Relation between virulence and antigenic structure of virulent and attenuated strains of S. enteritidis. Jpn J Exp Med. 1959 Feb;29(1):1–8. [PubMed] [Google Scholar]
- MITSUHASHI S., KAWAKAMI M., YAMAGUCHI Y., NAGAI M. Studies on the experimental typhoid. 1. A comparative study of living and killed vaccines against the infection of mice with S. enteritidis. Jpn J Exp Med. 1958 Aug;28(4):249–258. [PubMed] [Google Scholar]