Table 4:
Factors associated with thyroid dysfunction
| Variable | Adjusted HR (95% CI) | p value |
|---|---|---|
| Taking a generic formulation of amiodarone (v. brand name) | 0.98 (0.88–1.09) | 0.69 |
| Strength of first dose (v. low) | ||
| Intermediate | 1.00 (0.89–1.14) | 0.95 |
| High | 1.11 (0.97–1.26) | 0.12 |
| Being a man | 0.76 (0.68–0.84) | < 0.01 |
| Age at admission to hospital for index event, per yr | 1.01 (1.00–1.02) | 0.02 |
| Median family income, per $ | 1.00 (0.99–1.00) | 0.06 |
| Baseline comorbidities in the year preceding the index event | ||
| Hypertension | 1.06 (0.95–1.17) | 0.31 |
| Coronary artery disease | 1.13 (1.00–1.27) | 0.05 |
| Heart failure | 1.09 (0.98–1.22) | 0.11 |
| COPD | 1.21 (1.08–1.35) | < 0.01 |
| Valvular disease | 0.94 (0.83–1.06) | 0.31 |
| Hyperlipidemia | 1.07 (0.95–1.20) | 0.27 |
| Diabetes | 1.03 (0.91–1.17) | 0.61 |
| Acute myocardial infarction | 0.91 (0.79–1.05) | 0.19 |
| Chronic renal failure | 1.10 (0.95–1.27) | 0.21 |
| Ischemic cerebrovascular disease (including TIA and retinal infarct) | 0.82 (0.65–1.04) | 0.10 |
| Any bleeding event | 0.82 (0.62–1.10) | 0.19 |
| Liver disease | 1.18 (0.86–1.62) | 0.30 |
Note: CI = confidence interval, COPD = chronic obstructive pulmonary disease, HR = hazard ratio, TIA = transient ischemic attack.