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. Author manuscript; available in PMC: 2012 Sep 13.
Published in final edited form as: Biochemistry. 2011 Aug 17;50(36):7774–7786. doi: 10.1021/bi200847n

Figure 4. G6-induced cleavage of vimentin is Jak2-mediated.

Figure 4

HEL cells were treated for 24 hrs with increasing concentrations of Jak2 specific inhibitors (G6, AG490 and Jak Inhibitor I) (A) or non-Jak2 inhibitors (MAPK inhibitor, PD98059 and c-Src inhibitor, PP2) (B). Whole cell lysates were separated by SDS-PAGE and immunoblotted with an anti-vimentin antibody. Loading of total protein across all lanes was determined using an anti-STAT1 antibody. Shown is one of three representative blots.