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. 2011 Oct 1;138(19):4255–4265. doi: 10.1242/dev.069054

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Fig. 7. — How reciprocal binding of two β-catenins to POP-1 drives target gene activation versus nuclear export. Proposed mechanisms by which two structurally and functionally distinct populations of POP-1 are generated in the nucleus of the signal-responsive cell. One population of POP-1 binds to SYS-1 leading to activation of Wnt target genes, and the other binds to WRM-1, leading to LIT-1 phosphorylation and POP-1 nuclear export. The first mechanism involves mutual inhibition of POP-1/WRM-1 versus POP-1/SYS-1 interactions. The second mechanism invokes phosphorylation of POP-1 T425 by an as yet unknown kinase, favoring a POP-1/SYS-1 interaction. These two mechanisms are not mutually exclusive.