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Identification of the ENU-induced Plk4 I242N heterozygous mutation. A, Genome-wide SNP mapping of DNA from affected F1 mice. Yellow indicates heterozygosity. B, Sequence variant in exon 5 of Plk4. C, Functional domains of PLK4 schematic. KD, Kinase domain; CPB, cryptic polo box; PB, polo box.
