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Activities of analogs with substituted piperazines (9a–f), piperidines (10a–c), quinazolinones (16a–e) and 17 in a cell-based reporter gene assay.
| Comp. | reporter gene (IC50, μM) | Comp. | reporter gene (IC50, μM) |
|---|---|---|---|
| 9a | 8.6 | 10c | Inactivea |
| 9c | 10.9 | 16a | 7.3 |
| 9d | 6.6 | 16b | 21b |
| 9e | Inactivea | 16c | Inactivea |
| 9f | 7.0b | 16d | 22b |
| 10a | Inactivea | 16e | Inactivea |
| 10b | 23.5 | 17 | Inactivea |
No activity at 20 μM.
Compound showed partial inhibition in reporter gene assay.
