TABLE 5.

Association of the HLA genes with IA-2A positivity in type 1 diabetic case subjects

Gene	Physical position*	Number of samples		P	P addition of locus to HLA-DRB1	P addition of locus to HLA-DRB1 and HLA-A*24
		IA-2A positive	IA-2A negative
HLA-DQB1	32,273,871–33,498,585	1,394	1,005	1.34 × 10−38	0.0094	0.0320
HLA-DRB1	32,485,163–32,557,625	1,390	1,007	1.94 × 10−41	NA	NA
HLA-B	31,237,115–31,324,989	893	647	2.69 × 10−9	0.5518	0.8631
HLA-C	31,236,526–31,323,369	752	516	2.42 × 10−6	0.1120	0.1290
MICA	31,367,561–31,384,016	1,410	983	2.67 × 10−6	0.2250	0.6640
HLA-A	29,909,037–29,913,661	1,005	716	5.50 × 10−9	6.13 × 10−6	NA

*Physical positions are from GRCh37 (www.t1dbase.org).